iPTMnet Report for Q9NQS3 (NECTIN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQS3 / NECT3_HUMAN
Protein Name Nectin-3 precursor
Gene Name Name: NECTIN3
Synonyms:PRR3,PVRL3;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQS3
DAG View
PRO Name nectin-3 (human)
Definition A nectin-3 that is encoded in the genome of human.
Short Label hNECTIN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQS3 (NECTIN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N73 N-Glycosylation GlyGen   UniProt 22902367
N125 N-Glycosylation GlyGen   UniProt 22902367
S141 O-Glycosylation GlyGen 35289036
N186 N-Glycosylation GlyGen   UniProt 22902367
N222 N-Glycosylation GlyGen   UniProt 22902367
N331 N-Glycosylation GlyGen   UniProt 22902367
T367 O-Glycosylation GlyGen 30459171
S373 O-Glycosylation GlyGen 30459171
T374 O-Glycosylation GlyGen 30459171
Y438 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
Y510 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
Y526 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y438 Phosphorylation HPRD 19901323
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N186 Y186 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S373 L373 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T374 P374 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K403 E403 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K451 T451 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
K451 N451 Biomuta DOID:1324 / lung cancer [ cosmic ]
K451 E451 Biomuta DOID:1324 / lung cancer [ icgc ]
S465 F465 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y510 H510 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K515 N515 Biomuta DOID:9256 / colorectal cancer [ cosmic ]