iPTMnet Report for Q9NQR4 (NIT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQR4 / NIT2_HUMAN
Protein Name Omega-amidase NIT2
Gene Name Name: NIT2
ORFNames:CUA002;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQR4
DAG View
PRO Name omega-amidase NIT2 (human)
Definition An omega-amidase NIT2 that is encoded in the genome of human.
Short Label hNIT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQR4 (NIT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation PhosphoSitePlus   UniProt 24275569
K37 Ubiquitination PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation HPRD   PhosphoSitePlus 15592455, 18083107
C146 Methylation IEDB 31844290
C146 S-Nitrosylation dbSNO 26338901
Y165 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
T237 Phosphorylation HPRD   PhosphoSitePlus 18452278
S244 Phosphorylation PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
R265 Methylation PhosphoSitePlus
S266 Phosphorylation HPRD   PhosphoSitePlus 17287340
Y269 Phosphorylation HPRD   PhosphoSitePlus 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 R68 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S207 F207 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K250 T250 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R265 Q265 Biomuta DOID:4159 / skin cancer [ cosmic ]
R265 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S266 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y269 F269 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]