iPTMnet Report for Q9NQC3 (RTN4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQC3 / RTN4_HUMAN
Protein Name Reticulon-4
Gene Name Name: RTN4
Synonyms:KIAA0886,NOGO;ORFNames:My043,SP1507;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQC3
DAG View
PRO Name reticulon-4 (human)
Definition A reticulon-4 that is encoded in the genome of human.
Short Label hRTN4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQC3 (RTN4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 19369195, 21406692, ...22223895, 22814378, 20068231, 25944712
S7 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S15 O-Glycosylation GlyGen 33214551, 34725712, 26853435, ...34019948, 35132862, 32119511, 36240223, 28510447, 33465208
S15 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
Y25 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S107 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 16095439, 17081983
S107 Phosphorylation P49137 (MAPKAPK2) Signor 16095439
S111 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
T172 Phosphorylation neXtProt   PhosphoSitePlus 22028470
T172 Phosphorylation P28482 (MAPK1) neXtProt 22028470
S181 O-Glycosylation GlyGen 33214551, 34725712, 26853435, ...34019948, 35132862, 32119511, 36240223, 28510447, 33465208
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S182 O-Glycosylation GlyGen 33214551, 34725712, 26853435, ...34019948, 35132862, 32119511, 36240223, 28510447, 33465208
S182 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S184 O-Glycosylation GlyGen 33214551, 34725712, 26853435, ...34019948, 35132862, 32119511, 36240223, 28510447, 33465208
S184 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T188 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S234 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
Y646 Phosphorylation PhosphoSitePlus
Y659 Phosphorylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
Y694 Phosphorylation PhosphoSitePlus 16979591
Y694 Phosphorylation P06241 (FYN) PhosphoSitePlus 16979591
Y718 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
S778 Phosphorylation PhosphoSitePlus
Y782 Phosphorylation PhosphoSitePlus
T813 O-Glycosylation GlyGen 33214551, 34725712, 26853435, ...34019948, 35132862, 32119511, 36240223, 28510447, 33465208
S823 Phosphorylation PhosphoSitePlus
Y840 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
T879 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
Y889 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
T945 Phosphorylation PhosphoSitePlus
S946 Phosphorylation PhosphoSitePlus
S991 Phosphorylation PhosphoSitePlus   UniProt 23186163
S993 Phosphorylation PhosphoSitePlus
K1002 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
S1067 Phosphorylation PhosphoSitePlus
K1090 Ubiquitination PhosphoSitePlus
C1101 Methylation IEDB 31844290
C1101 S-Nitrosylation dbSNO 19483679, 2212679, 25040305, ...20140087, 22126794, 22178444
K1104 Acetylation PhosphoSitePlus   UniProt 19608861
K1104 Ubiquitination PhosphoSitePlus
S1150 Phosphorylation PhosphoSitePlus
Y1165 Phosphorylation PhosphoSitePlus
K1171 Ubiquitination PhosphoSitePlus
K1174 Ubiquitination PhosphoSitePlus
K1179 Ubiquitination PhosphoSitePlus
K1183 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 19413330, 18578522, 18491316, ...17081983, 20068231
S11 Phosphorylation HPRD 18578522, 17081983, 20068231
S12 Phosphorylation HPRD 19413330, 18578522, 20068231
S13 Phosphorylation HPRD 17081983, 20068231, 18452278
S15 Phosphorylation HPRD 19413330, 18691976, 18578522, ...18491316, 17081983, 20058876, 19007248, 19651622, 20068231
S107 Phosphorylation HPRD 20058876, 17081983, 20068231, ...18707149
S181 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S182 Phosphorylation HPRD 19651622, 18578522, 18669648, ...20068231, 18452278
S184 Phosphorylation HPRD 19651622, 18578522, 20230923, ...18669648, 17081983
T188 Phosphorylation HPRD 18578522, 17081983, 20230923, ...19651622, 18669648, 20068231
S196 Phosphorylation HPRD 17081983
S515 Phosphorylation HPRD 19413330
S525 Phosphorylation HPRD 19413330
Y529 Phosphorylation HPRD 19413330
S860 Phosphorylation HPRD 15345747
S863 Phosphorylation HPRD 15345747
S943 Phosphorylation HPRD 18491316
S991 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD   neXtProt 19413330, 18578522, 18491316, ...17081983, 16095439, 20068231
S7 Phosphorylation P49137 (MAPKAPK2) neXtProt 16095439
S11 Phosphorylation HPRD 18578522, 17081983, 20068231
S12 Phosphorylation HPRD 19413330, 18578522, 20068231
S13 Phosphorylation HPRD 17081983, 20068231, 18452278
S15 Phosphorylation HPRD   neXtProt 19413330, 18691976, 18578522, ...18491316, 17081983, 18072206, 20058876, 19007248, 19651622, 20068231
S107 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20058876, 18707149, ...16095439, 20068231
S107 Phosphorylation P49137 (MAPKAPK2) PhosphoSitePlus 16095439
S181 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S184 Phosphorylation HPRD   PhosphoSitePlus 18578522
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation HPRD 19413330, 18578522, 18491316, ...17081983, 20068231
S11 Phosphorylation HPRD 18578522, 17081983, 20068231
S12 Phosphorylation HPRD 19413330, 18578522, 20068231
S13 Phosphorylation HPRD 17081983, 20068231, 18452278
S15 Phosphorylation HPRD 19413330, 18691976, 18578522, ...18491316, 17081983, 20058876, 19007248, 19651622, 20068231
S107 Phosphorylation HPRD 20058876, 17081983, 20068231, ...18707149
S181 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S182 Phosphorylation HPRD 19651622, 18578522, 18669648, ...20068231, 18452278
S184 Phosphorylation HPRD 19651622, 18578522, 20230923, ...18669648, 17081983
T188 Phosphorylation HPRD 18578522, 17081983, 20230923, ...19651622, 18669648, 20068231
S196 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S309 Phosphorylation HPRD 19413330
S319 Phosphorylation HPRD 19413330
Y323 Phosphorylation HPRD 19413330
S654 Phosphorylation HPRD 15345747
S657 Phosphorylation HPRD 15345747
S737 Phosphorylation HPRD 18491316
S785 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 L11 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S13 W13 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S115 W115 Biomuta DOID:4159 / skin cancer [ cosmic ]
S152 G152 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T172 P172 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S234 C234 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S319 F319 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y384 C384 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T450 M450 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S525 F525 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y840 H840 Biomuta DOID:363 / uterine cancer [ icgc ]
T945 A945 Biomuta DOID:4159 / skin cancer [ cosmic ]
S993 P993 Biomuta DOID:10283 / prostate cancer [ cosmic, cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc, cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K1104 E1104 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1150 G1150 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]