Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NQB0 / TF7L2_HUMAN
Protein Name Transcription factor 7-like 2
Gene Name Name: TCF7L2
Organism Homo sapiens (Human)

DAG View
PRO Name transcription factor 7-like 2 (human)
Definition A transcription factor 7-like 2 that is encoded in the genome of human.
Short Label hTCF7L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NQB0 (TCF7L2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K22 Sumoylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S58 Phosphorylation phospho.ELM   PhosphoSitePlus 11711551
S59 Phosphorylation phospho.ELM   PhosphoSitePlus 11711551
S60 Phosphorylation phospho.ELM   PhosphoSitePlus 11711551
S74 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
R126 Methylation PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
S177 Phosphorylation Q9UKE5 (TNIK) neXtProt   PhosphoSitePlus   Signor 20530691
S179 Phosphorylation PhosphoSitePlus
T201 Phosphorylation Q9UBE8 (NLK) neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 12556497
T212 Phosphorylation Q9UBE8 (NLK) neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 12556497
S324 Phosphorylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
Y400 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
K563 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K132 Ubiquitination PhosphoSitePlus
K433 Sumoylation PhosphoSitePlus
K442 Sumoylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049408 (hTCF7L2/Phos:1) pT201,pT212 PRO

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037190 (hCTNNB1/iso:1/Phos:7) decreased Interaction PR:Q9NQB0 (hTCF7L2) PRO 23617586

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 Y59 Biomuta DOID:3070 / malignant glioma [ tcga ]
S74 T74 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K173 N173 Biomuta DOID:363 / uterine cancer [ tcga ]
S177 Y177 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T212 M212 Biomuta DOID:1324 / lung cancer [ tcga ]
K335 N335 Biomuta DOID:3571 / liver cancer [ icgc ]
K367 N367 Biomuta DOID:3571 / liver cancer [ icgc ]
S418 Y418 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S418 F418 Biomuta DOID:1115 / sarcoma [ tcga ]