iPTMnet Report for Q9NQ88 (TIGAR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQ88 / TIGAR_HUMAN
Protein Name Fructose-2,6-bisphosphatase TIGAR
Gene Name Name: TIGAR
Synonyms:C12orf5;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQ88
DAG View
PRO Name fructose-2,6-bisphosphatase TIGAR (human)
Definition A fructose-2,6-bisphosphatase TIGAR that is encoded in the genome of human.
Short Label hTIGAR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQ88 (TIGAR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K20 Ubiquitination PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
K37 Methylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K50 Acetylation PhosphoSitePlus   UniProt 19608861
R61 Methylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S154 Phosphorylation HPRD   PhosphoSitePlus 17525332, 18077418, 20068231
S157 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S184 Phosphorylation HPRD 20068231
S192 Phosphorylation HPRD 20068231
S204 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 N20 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K50 N50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T80 M80 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T80 R80 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S85 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S154 F154 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S184 R184 Biomuta DOID:363 / uterine cancer [ icgc ]
S192 I192 Biomuta DOID:3571 / liver cancer [ cosmic ]