iPTMnet Report for Q9NQ75 (CASS4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQ75 / CASS4_HUMAN
Protein Name Cas scaffolding protein family member 4
Gene Name Name: CASS4
Synonyms:C20orf32,HEFL;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQ75
DAG View
PRO Name Cas scaffolding protein family member 4 (human)
Definition A Cas scaffolding protein family member 4 that is encoded in the genome of human.
Short Label hCASS4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQ75 (CASS4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
S200 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163
Y231 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
S249 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163
S274 Phosphorylation PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
S305 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163
S311 Phosphorylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
Y329 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T345 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S376 Phosphorylation PhosphoSitePlus   UniProt 23186163
T388 Phosphorylation PhosphoSitePlus
S390 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18088087
S401 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
T418 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
Y679 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S200 Phosphorylation HPRD 18088087
S249 Phosphorylation HPRD 18088087
S305 Phosphorylation HPRD 18088087
Y329 Phosphorylation HPRD 18083107
Y350 Phosphorylation HPRD 18083107
S390 Phosphorylation HPRD 18088087
Site PTM Type PTM Enzyme Score Source PMID
S211 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y98 C98 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S118 N118 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T127 I127 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S165 L165 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S171 F171 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y174 H174 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S211 N211 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S232 I232 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S249 P249 Biomuta DOID:363 / uterine cancer [ icgc ]
S311 F311 Biomuta DOID:4159 / skin cancer [ cosmic ]
S328 N328 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T345 N345 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y350 N350 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S434 F434 Biomuta DOID:4159 / skin cancer [ cosmic ]
T597 N597 Biomuta DOID:10283 / prostate cancer [ cosmic ]