iPTMnet Report for Q9NQ66 (PLCB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NQ66 / PLCB1_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Gene Name Name: PLCB1
Synonyms:KIAA0581;
Organism Homo sapiens (Human)

PRO ID PR:Q9NQ66
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 that is encoded in the genome of human.
Short Label hPLCB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NQ66 (PLCB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T26 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
T187 O-Glycosylation GlyGen 30379171
S196 O-Glycosylation GlyGen 30379171
S197 O-Glycosylation GlyGen 30379171
K423 Ubiquitination PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S473 O-Glycosylation GlyGen 30379171
S500 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
Y816 Phosphorylation PhosphoSitePlus
S887 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 21338571, 11278470
S918 Phosphorylation PhosphoSitePlus
K972 Acetylation PhosphoSitePlus
K976 Acetylation PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
S982 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) phospho.ELM   PhosphoSitePlus 11287604
S987 Phosphorylation PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
Y1024 Phosphorylation PhosphoSitePlus
Y1025 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
K1074 Acetylation PhosphoSitePlus
K1075 Acetylation PhosphoSitePlus
Y1102 Phosphorylation PhosphoSitePlus
Y1109 Phosphorylation PhosphoSitePlus
S1199 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S569 Phosphorylation HPRD 17924679
T573 Phosphorylation HPRD 17924679
S887 Phosphorylation P17252 (PRKCA) , Q05655 (PRKCD) HPRD 11278470
S918 Phosphorylation HPRD 18578522
S982 Phosphorylation P27361 (MAPK3) HPRD 11287604
Site PTM Type PTM Enzyme Score Source PMID
S569 Phosphorylation HPRD 17924679
T573 Phosphorylation HPRD 17924679
S887 Phosphorylation Q05655 (PRKCD) , P17252 (PRKCA) HPRD 11278470
S918 Phosphorylation HPRD 18578522
S982 Phosphorylation P27361 (MAPK3) HPRD 11287604


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T26 A26 Biomuta DOID:3565 / meningioma [ cosmic ]
Y107 H107 Biomuta DOID:3571 / liver cancer [ cosmic ]
S196 F196 Biomuta DOID:4159 / skin cancer [ cosmic ]
S197 L197 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K423 E423 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S473 L473 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S501 Y501 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T509 M509 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S558 L558 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S558 P558 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S569 F569 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S569 Y569 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K735 T735 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T802 K802 Biomuta DOID:1324 / lung cancer [ cosmic ]
S918 L918 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K972 N972 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K976 R976 Biomuta DOID:4159 / skin cancer [ cosmic ]
S978 L978 Biomuta DOID:4159 / skin cancer [ cosmic ]
S978 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S981 N981 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y1024 C1024 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1024 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K1074 T1074 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1199 Y1199 Biomuta DOID:5041 / esophageal cancer [ cosmic ]