iPTMnet Report for Q9NPQ8 (RIC8A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NPQ8 / RIC8A_HUMAN
Protein Name Synembryn-A
Gene Name Name: RIC8A
Organism Homo sapiens (Human)

PRO ID PR:Q9NPQ8
DAG View
PRO Name synembryn-A (human)
Definition A synembryn-A that is encoded in the genome of human.
Short Label hRIC8A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NPQ8 (RIC8A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T12 Phosphorylation PhosphoSitePlus
Y25 Phosphorylation PhosphoSitePlus
S30 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S32 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
T324 Phosphorylation IEDB   PhosphoSitePlus 27869121
K328 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus   RLIMS-P 27096001
S436 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 27096001, 18669648, ...19690332, 20068231
T441 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 27096001, 18669648, ...24275569, 19690332, 20068231
T443 Phosphorylation PhosphoSitePlus   RLIMS-P 27096001
Y446 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S523 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S524 Phosphorylation PhosphoSitePlus   UniProt 18669648, 24275569
S528 Phosphorylation PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation HPRD 17525332, 18077418
Y441 Phosphorylation HPRD 18691976, 19651622, 18669648, ...20166139, 19415658, 20068231
S442 Phosphorylation HPRD 18691976, 19664994, 19651622, ...18669648, 20166139, 19415658, 20068231
T447 Phosphorylation HPRD 18691976, 19651622, 18669648, ...20166139, 19415658, 20068231
T449 Phosphorylation HPRD 19651622, 18669648, 19664994
Y452 Phosphorylation HPRD 20166139, 18669648
S508 Phosphorylation HPRD 18691976, 18669648, 18212344, ...20068231, 19415658
S529 Phosphorylation HPRD 18669648
S530 Phosphorylation HPRD 18669648
S534 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S74 Y74 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S74 P74 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T199 M199 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc, tcga ]
T203 A203 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T441 K441 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T441 A441 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y446 N446 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T447 K447 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T447 A447 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y452 N452 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T485 N485 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S523 F523 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S529 F529 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]