iPTMnet Report for Q9NPI6 (DCP1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NPI6 / DCP1A_HUMAN
Protein Name mRNA-decapping enzyme 1A
Gene Name Name: DCP1A
Synonyms:SMIF;
Organism Homo sapiens (Human)

PRO ID PR:Q9NPI6
DAG View
PRO Name mRNA-decapping enzyme 1A (human)
Definition An mRNA-decapping enzyme 1A that is encoded in the genome of human.
Short Label hDCP1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NPI6 (DCP1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y64 Phosphorylation PhosphoSitePlus
Y97 Phosphorylation IEDB 35494241
K120 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
S142 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S144 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S176 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S180 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S186 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S239 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
T290 Phosphorylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
Y310 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21859862, 21406692, 23300942, ...23186163, 18691976, 18220336, 18669648, 19690332, 20068231
S315 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 21859862
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...18220336
T321 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S339 O-Glycosylation GlyGen 28314751
T340 O-Glycosylation GlyGen 28314751
T340 Phosphorylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus   UniProt 23186163
S353 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...18669648, 24275569, 20068231
S373 Phosphorylation PhosphoSitePlus
R376 Methylation PhosphoSitePlus   UniProt 24129315
T382 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
S388 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
K397 Ubiquitination PhosphoSitePlus
T401 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S422 Phosphorylation PhosphoSitePlus   UniProt 20068231
T430 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
T491 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 32938750, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
T493 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
T494 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
T495 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 32938750, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
S498 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 32938750, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
S499 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
S515 O-Glycosylation GlyGen 23301498, 33214551, 28314751, ...35138101, 35254053, 34019948, 22661428, 32119511, 29351928, 31373491
K520 Ubiquitination PhosphoSitePlus
S522 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S523 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163, ...19690332
S525 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...19690332
T528 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T531 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...18220336
S534 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S543 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S545 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T550 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q07352 (ZFP36L1) S334 Q9NPI6 (DCP1A) unknown eFIP 27708140


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S186 G186 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T195 I195 Biomuta DOID:363 / uterine cancer [ cosmic ]
T493 M493 Biomuta DOID:1324 / lung cancer [ cosmic ]
S498 F498 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ]
K537 * Biomuta DOID:263 / kidney cancer [ cosmic ]