iPTMnet Report for Q9NPF5 (DMAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NPF5 / DMAP1_HUMAN
Protein Name DNA methyltransferase 1-associated protein 1
Gene Name Name: DMAP1
Synonyms:KIAA1425;
Organism Homo sapiens (Human)

PRO ID PR:Q9NPF5
DAG View
PRO Name DNA methyltransferase 1-associated protein 1 (human)
Definition A DNA methyltransferase 1-associated protein 1 that is encoded in the genome of human.
Short Label hDMAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NPF5 (DMAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 20068231
K27 Ubiquitination PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
S41 Phosphorylation HPRD   PhosphoSitePlus 20068231
S42 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus   RLIMS-P 30553276
K270 Ubiquitination PhosphoSitePlus
T273 Phosphorylation HPRD 20068231
T284 Phosphorylation PhosphoSitePlus
K297 Acetylation PhosphoSitePlus
K301 Acetylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K316 Methylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
T409 O-Glycosylation GlyGen 34019948, 30620550, 36240223, ...21740066, 35254053
T409 Phosphorylation HPRD   PhosphoSitePlus 20068231
S412 Phosphorylation PhosphoSitePlus
S418 O-Glycosylation GlyGen 34019948, 30620550, 36240223, ...21740066, 35254053
S418 Phosphorylation PhosphoSitePlus
T424 O-Glycosylation GlyGen 32938750, 21740066, 30620550, ...34019948, 36240223, 35254053
T435 Phosphorylation PhosphoSitePlus
T445 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 18767875, 18847512, 20058876, 19664995, 18452278, 17322306, 18669648, 24275569, 19690332, 20068231, 17081983
S448 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus   UniProt 18847512, 19664995, 19690332
K450 Acetylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
S456 Phosphorylation HPRD   PhosphoSitePlus 17924679
S457 Phosphorylation HPRD   PhosphoSitePlus 20068231
S458 Phosphorylation HPRD 20068231
S459 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43684 (BUB3) S211 Q9NPF5 (DMAP1) unknown eFIP 30553276
Phosphorylation Q9NPF5 (DMAP1) Y246 O43684 (BUB3) inhibited_association eFIP 30553276


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K86 R86 Biomuta DOID:363 / uterine cancer [ icgc ]
T284 M284 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K311 R311 Biomuta DOID:263 / kidney cancer [ cosmic ]
S353 N353 Biomuta DOID:4159 / skin cancer [ cosmic ]
T357 M357 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T409 A409 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T424 S424 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S454 L454 Biomuta DOID:10283 / prostate cancer [ cosmic ]