iPTMnet Report for Q9NP87 (POLM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NP87 / DPOLM_HUMAN
Protein Name DNA-directed DNA/RNA polymerase mu
Gene Name Name: POLM
Synonyms:polmu;
Organism Homo sapiens (Human)

PRO ID PR:Q9NP87
DAG View
PRO Name DNA-directed DNA/RNA polymerase mu (human)
Definition A DNA-directed DNA/RNA polymerase mu that is encoded in the genome of human.
Short Label hPOLM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NP87 (POLM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18669648, 24275569, ...23933132, 19690332
S14 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus   RLIMS-P 23933132
T95 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus   RLIMS-P 23933132
S372 Phosphorylation P24941 (CDK2) PhosphoSitePlus 23933132
K452 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 19413330, 18669648, 19664994
Site PTM Type PTM Enzyme Score Source PMID
K277 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K372 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 N14 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S19 Y19 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T21 M21 Biomuta DOID:4159 / skin cancer [ cosmic ]
T21 K21 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K187 R187 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K238 Q238 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K238 R238 Biomuta DOID:9256 / colorectal cancer [ cosmic ]