Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NP80 / PLPL8_HUMAN
Protein Name Calcium-independent phospholipase A2-gamma
Gene Name Name: PNPLA8
Synonyms:IPLA22,IPLA2G;ORFNames:BM-043;
Organism Homo sapiens (Human)

PRO ID PR:Q9NP80
DAG View
PRO Name calcium-independent phospholipase A2-gamma (human)
Definition A calcium-independent phospholipase A2-gamma that is encoded in the genome of human.
Short Label hPNPLA8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NP80 (PNPLA8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S89 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
R125 Methylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S511 Phosphorylation Q9BUB5 (MKNK1) PhosphoSitePlus 23258543
S515 Phosphorylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
Y663 Phosphorylation PhosphoSitePlus
T670 Phosphorylation PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S89 C89 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S102 P102 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R125 C125 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S347 Y347 Biomuta DOID:363 / uterine cancer [ tcga ]
S511 * Biomuta DOID:3571 / liver cancer [ icgc ]
T670 M670 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K736 E736 Biomuta DOID:9256 / colorectal cancer [ tcga ]