iPTMnet Report for Q9NP31 (SH2D2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NP31 / SH22A_HUMAN
Protein Name SH2 domain-containing protein 2A
Gene Name Name: SH2D2A
Synonyms:SCAP,TSAD,VRAP;
Organism Homo sapiens (Human)

PRO ID PR:Q9NP31
DAG View
PRO Name SH2 domain-containing protein 2A (human)
Definition An SH2 domain-containing protein 2A that is encoded in the genome of human.
Short Label hSH2D2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NP31 (SH2D2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y39 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S43 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K221 Ubiquitination PhosphoSitePlus
Y260 Phosphorylation P06239 (LCK) PhosphoSitePlus   RLIMS-P 26163016, 18541536
T261 Phosphorylation PhosphoSitePlus
Y280 Phosphorylation P06239 (LCK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26163016, 18541536, 16497976
Y290 Phosphorylation P06239 (LCK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18541536, 16497976
R294 Methylation PhosphoSitePlus
S296 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S302 Phosphorylation PhosphoSitePlus
Y305 Phosphorylation P06239 (LCK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15592455, 26163016, 18541536
S371 Phosphorylation PhosphoSitePlus
R378 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y216 Phosphorylation HPRD 15592455, 19901323, 16497976
S217 Phosphorylation HPRD 18669648
Y280 Phosphorylation HPRD 16497976
Y290 Phosphorylation HPRD 16497976
S296 Phosphorylation HPRD 18669648
Y305 Phosphorylation HPRD 16497976
Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
Y21 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06239 (LCK) Y192 Q9NP31 (SH2D2A) unknown eFIP 27014263


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 I5 Biomuta [ cosmic ]
Y21 C21 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y39 C39 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K221 R221 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R294 L294 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R294 W294 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R294 Q294 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R294 P294 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R378 S378 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R378 K378 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]