iPTMnet Report for Q9NNW7 (TXNRD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NNW7 / TRXR2_HUMAN
Protein Name Thioredoxin reductase 2, mitochondrial precursor
Gene Name Name: TXNRD2
Synonyms:KIAA1652,TRXR2;
Organism Homo sapiens (Human)

PRO ID PR:Q9NNW7
DAG View
PRO Name thioredoxin reductase 2, mitochondrial (human)
Definition A thioredoxin reductase 2, mitochondrial that is encoded in the genome of human.
Short Label hTXNRD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NNW7 (TXNRD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y40 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K175 Acetylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
K506 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y40 Phosphorylation HPRD 20068231
S335 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T238 I238 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]