iPTMnet Report for Q9NNW5 (WDR6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NNW5 / WDR6_HUMAN
Protein Name tRNA (34-2'-O)-methyltransferase regulator WDR6
Gene Name Name: WDR6
Organism Homo sapiens (Human)

PRO ID PR:Q9NNW5
DAG View
PRO Name WD repeat-containing protein 6 (human)
Definition A WD repeat-containing protein 6 that is encoded in the genome of human.
Short Label hWDR6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NNW5 (WDR6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
K90 Ubiquitination PhosphoSitePlus
C164 Methylation IEDB 31844290
K237 Ubiquitination PhosphoSitePlus
S273 Phosphorylation IEDB 32387766
K343 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
C380 Methylation IEDB 31844290
K418 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
C464 Methylation IEDB 31844290
K490 Ubiquitination PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
Y592 Phosphorylation PhosphoSitePlus
K647 Acetylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
C771 Methylation IEDB 31844290
K855 Ubiquitination PhosphoSitePlus
S896 Phosphorylation PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
T991 Phosphorylation PhosphoSitePlus
C1042 Methylation IEDB 31844290
K1052 Ubiquitination PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:4159 / skin cancer [ icgc ]
K343 R343 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S514 F514 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y592 F592 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y592 H592 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S896 A896 Biomuta DOID:363 / uterine cancer [ icgc ]