iPTMnet Report for Q9HDC5 (JPH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HDC5 / JPH1_HUMAN
Protein Name Junctophilin-1
Gene Name Name: JPH1
Synonyms:JP1;
Organism Homo sapiens (Human)

PRO ID PR:Q9HDC5
DAG View
PRO Name junctophilin-1 (human)
Definition A junctophilin-1 that is encoded in the genome of human.
Short Label hJPH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HDC5 (JPH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K77 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S157 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T161 Phosphorylation PhosphoSitePlus
S162 Phosphorylation HPRD   PhosphoSitePlus 19691289
S165 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
S216 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...20068231
S220 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S238 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S296 O-Glycosylation GlyGen 30620550
K373 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
T448 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18767875, ...19651622, 18669648, 20068231
S452 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18767875, 19651622, ...18669648, 20068231
T460 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648
T461 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163
S465 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163
S469 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163
S473 Phosphorylation HPRD 17081983
S475 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
S478 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S479 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S548 Phosphorylation PhosphoSitePlus
Y550 Phosphorylation PhosphoSitePlus
Y553 Phosphorylation PhosphoSitePlus
Y554 Phosphorylation PhosphoSitePlus
S573 Phosphorylation HPRD 17081983
S577 Phosphorylation HPRD 17081983
S585 Phosphorylation HPRD 17081983
S590 Phosphorylation PhosphoSitePlus
S592 Phosphorylation HPRD   PhosphoSitePlus 17081983
K611 Ubiquitination PhosphoSitePlus
S625 Phosphorylation HPRD   PhosphoSitePlus 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T153 M153 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T161 S161 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S162 L162 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ icgc ]
S216 F216 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T460 M460 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T460 A460 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S548 F548 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S548 C548 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S573 P573 Biomuta DOID:1319 / brain cancer [ cosmic ]
S573 Y573 Biomuta DOID:3571 / liver cancer [ cosmic ]
S585 F585 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S592 F592 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ]