Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HD40 / SPCS_HUMAN
Protein Name O-phosphoseryl-tRNA(Sec) selenium transferase
Gene Name Name: SEPSECS
Synonyms:TRNP48;
Organism Homo sapiens (Human)

PRO ID PR:Q9HD40
DAG View
PRO Name O-phosphoseryl-tRNA(Sec) selenium transferase (human)
Definition An O-phosphoseryl-tRNA(Sec) selenium transferase that is encoded in the genome of human.
Short Label hSEPSECS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HD40 (SEPSECS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus   UniProt 23186163
R90 Methylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S501 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S120 Y120 Biomuta DOID:363 / uterine cancer [ tcga ]
Y255 C255 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y417 C417 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y473 C473 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]