iPTMnet Report Q9HCN4 GPN1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9HCN4 / GPN1_HUMAN
Protein Name	GPN-loop GTPase 1
Gene Name	Name: GPN1 Synonyms:MBDIN,RPAP4;ORFNames:HUSSY-23;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9HCN4 DAG View
PRO Name	GPN-loop GTPase 1 (human)
Definition	A GPN-loop GTPase 1 that is encoded in the genome of human.
Short Label	hGPN1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9HCN4 (GPN1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	A2	Acetylation		score1	UniProt	22814378, 22223895
	S4	Phosphorylation		score1	PhosphoSitePlus
	S13	Phosphorylation		score1	PhosphoSitePlus
	T40	Phosphorylation		score1	PhosphoSitePlus
	K111	Ubiquitination		score1	PhosphoSitePlus
	C174	Methylation		score1	IEDB	31844290
	K278	Ubiquitination		score1	PhosphoSitePlus
	K297	Ubiquitination		score1	PhosphoSitePlus
	S301	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
	T308	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
	K310	Ubiquitination		score1	PhosphoSitePlus
	S312	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 24275569, 18220336
	S314	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	21406692, 23186163, 18220336, ...18669648, 20068231
	T328	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
	S338	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	20068231, 18669648, 21406692, ...24275569
	T340	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163, 24275569
	K370	Methylation		score1	PhosphoSitePlus
	K370	Ubiquitination		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T13	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
A2	V2	Biomuta		DOID:5041 / esophageal cancer [ cosmic, icgc ]
S312	I312	Biomuta		DOID:2998 / testicular cancer [ cosmic ]