iPTMnet Report for Q9HCK8 (CHD8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCK8 / CHD8_HUMAN
Protein Name Chromodomain-helicase-DNA-binding protein 8
Gene Name Name: CHD8
Synonyms:HELSNF1,KIAA1564;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCK8
DAG View
PRO Name chromodomain-helicase-DNA-binding protein 8 (human)
Definition A chromodomain-helicase-DNA-binding protein 8 that is encoded in the genome of human.
Short Label hCHD8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCK8 (CHD8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S113 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 29351928, 35132862, 32119511, 35254053
T114 O-Glycosylation GlyGen 32938750
S117 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 29351928, 35132862, 32119511, 35254053
S123 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32938750, 34019948, 29351928, 35132862, 32119511, 35254053
S125 Phosphorylation PhosphoSitePlus
S169 O-Glycosylation GlyGen 34846842
T171 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 29351928, 35132862, 32119511, 35254053
T184 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 29351928, 35132862, 32119511, 35254053
T207 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S256 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 29351928, 35132862, 32119511, 35254053
K270 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K399 Acetylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus   UniProt 23186163
S435 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
T444 Phosphorylation IEDB 32387766
T527 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
T535 Phosphorylation PhosphoSitePlus
T537 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus   UniProt 19690332
S562 Phosphorylation PhosphoSitePlus   UniProt 18669648
K592 Sumoylation PhosphoSitePlus
K609 Sumoylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K1013 Ubiquitination PhosphoSitePlus
K1020 Ubiquitination PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
K1093 Ubiquitination PhosphoSitePlus
Y1099 Phosphorylation PhosphoSitePlus
K1140 Ubiquitination PhosphoSitePlus
R1202 Methylation PhosphoSitePlus
K1250 Acetylation PhosphoSitePlus
K1270 Ubiquitination PhosphoSitePlus
K1274 Ubiquitination PhosphoSitePlus
K1279 Ubiquitination PhosphoSitePlus
S1286 O-Glycosylation GlyGen 31373491
K1300 Ubiquitination PhosphoSitePlus
K1301 Acetylation PhosphoSitePlus
K1301 Ubiquitination PhosphoSitePlus
K1309 Ubiquitination PhosphoSitePlus
K1354 Ubiquitination PhosphoSitePlus
R1363 Methylation PhosphoSitePlus
K1376 Ubiquitination PhosphoSitePlus
K1380 Ubiquitination PhosphoSitePlus
K1391 Ubiquitination PhosphoSitePlus
T1398 Phosphorylation PhosphoSitePlus
S1420 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332, 20068231
S1424 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332, 20068231
S1432 Phosphorylation PhosphoSitePlus
S1466 Phosphorylation PhosphoSitePlus
T1475 Phosphorylation PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
S1523 Phosphorylation PhosphoSitePlus
S1526 Phosphorylation PhosphoSitePlus
K1539 Ubiquitination PhosphoSitePlus
S1540 Phosphorylation PhosphoSitePlus
K1548 Ubiquitination PhosphoSitePlus
K1554 Ubiquitination PhosphoSitePlus
K1567 Ubiquitination PhosphoSitePlus
S1632 Phosphorylation PhosphoSitePlus
Y1642 Phosphorylation IEDB 35494241
K1644 Ubiquitination PhosphoSitePlus
K1659 Ubiquitination PhosphoSitePlus
K1666 Acetylation PhosphoSitePlus
K1666 Ubiquitination PhosphoSitePlus
S1679 Phosphorylation PhosphoSitePlus
K1689 Ubiquitination PhosphoSitePlus
K1697 Sumoylation PhosphoSitePlus
K1697 Ubiquitination PhosphoSitePlus
K1766 Ubiquitination PhosphoSitePlus
S1842 Phosphorylation PhosphoSitePlus
S1976 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1978 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1981 Phosphorylation PhosphoSitePlus
T1982 Phosphorylation PhosphoSitePlus
Y1989 Phosphorylation PhosphoSitePlus
T1990 Phosphorylation PhosphoSitePlus
S1991 Phosphorylation PhosphoSitePlus
T1993 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1995 Phosphorylation PhosphoSitePlus
S2008 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
T2012 Phosphorylation PhosphoSitePlus
T2014 Phosphorylation PhosphoSitePlus
S2018 Phosphorylation PhosphoSitePlus
K2025 Ubiquitination PhosphoSitePlus
T2037 Phosphorylation PhosphoSitePlus
Y2041 Phosphorylation PhosphoSitePlus
R2044 Methylation PhosphoSitePlus
S2046 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S2048 Phosphorylation PhosphoSitePlus
T2050 Phosphorylation PhosphoSitePlus
T2051 Phosphorylation PhosphoSitePlus   UniProt 16964243
S2055 Phosphorylation PhosphoSitePlus
S2069 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2071 Phosphorylation PhosphoSitePlus   UniProt 21406692
S2076 Phosphorylation PhosphoSitePlus
S2083 Phosphorylation PhosphoSitePlus
S2084 Phosphorylation PhosphoSitePlus
S2085 Phosphorylation PhosphoSitePlus
S2086 Phosphorylation PhosphoSitePlus
S2087 Phosphorylation PhosphoSitePlus
S2126 Phosphorylation PhosphoSitePlus
S2182 Phosphorylation PhosphoSitePlus   UniProt 18220336
S2200 Phosphorylation PhosphoSitePlus   UniProt 19690332
S2202 Phosphorylation PhosphoSitePlus
T2204 Phosphorylation PhosphoSitePlus
S2211 Phosphorylation PhosphoSitePlus   UniProt 18220336
T2215 Phosphorylation PhosphoSitePlus
S2223 Phosphorylation PhosphoSitePlus
K2241 Ubiquitination PhosphoSitePlus
K2256 Sumoylation PhosphoSitePlus
K2262 Ubiquitination PhosphoSitePlus
K2267 Ubiquitination PhosphoSitePlus
K2269 Ubiquitination PhosphoSitePlus
K2286 Acetylation PhosphoSitePlus
K2320 Ubiquitination PhosphoSitePlus
K2394 Ubiquitination PhosphoSitePlus
R2404 Methylation PhosphoSitePlus
S2414 Phosphorylation PhosphoSitePlus
K2416 Ubiquitination PhosphoSitePlus
Y2516 Phosphorylation PhosphoSitePlus
S2518 Phosphorylation PhosphoSitePlus
S2519 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 29351928, 35132862, 32119511, 35254053
S2519 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T2522 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...35132862, 29351928, 34019948, 32119511, 35254053, 31373491
T2522 Phosphorylation PhosphoSitePlus
T2523 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...34019948, 29351928, 35132862, 32119511, 35254053
S2525 Phosphorylation PhosphoSitePlus
T2527 O-Glycosylation GlyGen 31373491
S2551 Phosphorylation PhosphoSitePlus
S2556 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S153 Phosphorylation HPRD 18669648
S161 Phosphorylation HPRD 18669648
T248 Phosphorylation HPRD 20068231
S252 Phosphorylation HPRD 20068231
T256 Phosphorylation HPRD 20068231
T258 Phosphorylation HPRD 16964243, 20068231
T269 Phosphorylation HPRD 18452278
S270 Phosphorylation HPRD 18452278
S271 Phosphorylation HPRD 18669648, 18452278
S274 Phosphorylation HPRD 18669648, 18452278
S283 Phosphorylation HPRD 18669648, 18452278
S1044 Phosphorylation HPRD 18767875
T1131 Phosphorylation HPRD 17081983
S1141 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S1145 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1697 Phosphorylation HPRD 19651622, 18669648, 20068231
S1699 Phosphorylation HPRD 19651622, 17081983, 20068231
T1714 Phosphorylation HPRD 18669648, 18452278
S1716 Phosphorylation HPRD 17322306, 18669648, 18452278
S1729 Phosphorylation HPRD 19413330, 19664994, 18452278, ...19651622, 18669648, 20068231
T1733 Phosphorylation HPRD 18669648
S1767 Phosphorylation HPRD 16964243, 20058876, 19664994, ...19007248, 19664995, 19651622, 18669648, 20068231
T1772 Phosphorylation HPRD 16964243
S1790 Phosphorylation HPRD 19651622, 17081983, 18452278
S1792 Phosphorylation HPRD 19651622, 17081983, 18452278
S1797 Phosphorylation HPRD 19651622
S1903 Phosphorylation HPRD 18452278
S2239 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19664995, 20068231
S2240 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19007248, 19664995
S2272 Phosphorylation HPRD 18077418, 18452278
S2277 Phosphorylation HPRD 18077418, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T114 M114 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S117 A117 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T209 I209 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S252 N252 Biomuta DOID:363 / uterine cancer [ cosmic ]
T258 P258 Biomuta DOID:4159 / skin cancer [ cosmic ]
T258 I258 Biomuta DOID:4159 / skin cancer [ cosmic ]
T269 N269 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S270 L270 Biomuta DOID:1324 / lung cancer [ cosmic ]
S271 Y271 Biomuta DOID:1324 / lung cancer [ cosmic ]
K285 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S409 F409 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S531 N531 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T537 P537 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T537 I537 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T548 N548 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S549 L549 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S550 Y550 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K655 N655 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T663 I663 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1026 E1026 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1093 N1093 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1141 P1141 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1202 H1202 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1300 E1300 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1300 N1300 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1380 N1380 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1420 P1420 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1466 F1466 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1632 L1632 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1697 F1697 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1699 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1976 F1976 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S1978 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1990 A1990 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2037 N2037 Biomuta DOID:1115 / sarcoma [ icgc ]
Y2041 C2041 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R2044 * Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S2083 F2083 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2200 N2200 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S2211 C2211 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S2223 P2223 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2239 P2239 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2272 Y2272 Biomuta DOID:363 / uterine cancer [ cosmic ]
K2286 N2286 Biomuta DOID:1324 / lung cancer [ cosmic ]
K2394 R2394 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2518 P2518 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T2523 I2523 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2525 P2525 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2551 Y2551 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]