iPTMnet Report for Q9HCI7 (MSL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCI7 / MSL2_HUMAN
Protein Name E3 ubiquitin-protein ligase MSL2
Gene Name Name: MSL2
Synonyms:KIAA1585,MSL2L1,RNF184;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCI7
DAG View
PRO Name E3 ubiquitin-protein ligase MSL2 (human)
Definition An E3 ubiquitin-protein ligase MSL2 that is encoded in the genome of human.
Short Label hMSL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCI7 (MSL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
Y20 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
C102 Methylation IEDB 31844290
K104 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
C107 Methylation IEDB 31844290
Y109 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K375 Sumoylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
K406 Acetylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus   UniProt 23186163
T449 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S349 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y20 H20 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K104 T104 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y109 H109 Biomuta DOID:363 / uterine cancer [ icgc ]
T217 M217 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S349 N349 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K379 N379 Biomuta DOID:363 / uterine cancer [ icgc ]
S419 F419 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K450 N450 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
S540 N540 Biomuta DOID:4159 / skin cancer [ cosmic ]