iPTMnet Report for Q9HCI6 (KIAA1586)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCI6 / K1586_HUMAN
Protein Name E3 SUMO-protein ligase KIAA1586
Gene Name Name: KIAA1586
Organism Homo sapiens (Human)

PRO ID PR:Q9HCI6
DAG View
PRO Name E3 SUMO-protein ligase KIAA1586 (human)
Definition A protein that is a translation product of the KIAA1586 gene in human.
Short Label hKIAA1586
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCI6 (KIAA1586) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K85 Sumoylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K218 Sumoylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S101 F101 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y448 D448 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y448 H448 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K456 N456 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K460 M460 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K467 E467 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S681 A681 Biomuta DOID:263 / kidney cancer [ cosmic ]