iPTMnet Report for Q9HCG8 (CWC22)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCG8 / CWC22_HUMAN
Protein Name Pre-mRNA-splicing factor CWC22 homolog
Gene Name Name: CWC22
Synonyms:KIAA1604,NCM;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCG8
DAG View
PRO Name pre-mRNA-splicing factor CWC22 homolog (human)
Definition A pre-mRNA-splicing factor CWC22 that is encoded in the genome of human.
Short Label hCWC22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCG8 (CWC22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Methylation PhosphoSitePlus
S3 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S27 Phosphorylation HPRD   PhosphoSitePlus 19651622
S28 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18452278
Y33 Phosphorylation HPRD 19651622
S39 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
Y45 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
R58 Methylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus   UniProt 21406692
S64 Phosphorylation PhosphoSitePlus
S91 Phosphorylation HPRD   PhosphoSitePlus 19413330
S93 Phosphorylation HPRD   PhosphoSitePlus 19413330
T101 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
S106 O-Glycosylation GlyGen 31373491
S106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus   UniProt 23186163
S792 Phosphorylation PhosphoSitePlus
Y797 Phosphorylation PhosphoSitePlus
S829 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
S831 Phosphorylation PhosphoSitePlus
K841 Methylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
S866 Phosphorylation HPRD   PhosphoSitePlus 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S39 Y39 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y53 C53 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S61 Y61 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S165 T165 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S578 C578 Biomuta DOID:4159 / skin cancer [ cosmic ]
K604 N604 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S727 I727 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S829 Y829 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S831 F831 Biomuta DOID:2531 / hematologic cancer [ cosmic ]