iPTMnet Report for Q9HCE7 (SMURF1)
Protein Information
| UniProt AC / UniProt ID | Q9HCE7 / SMUF1_HUMAN |
| Protein Name | E3 ubiquitin-protein ligase SMURF1 |
| Gene Name | Name: SMURF1 Synonyms:KIAA1625; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9HCE7 |
| PRO Name | E3 ubiquitin-protein ligase SMURF1 (human) |
| Definition | An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human. |
| Short Label | hSMURF1 |
| Category | organism-gene |
DAG ViewQ9HCE7 (SMURF1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y66 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T145 | Phosphorylation | score0 | RLIMS-P | 27036023 | ||
| S148 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S200 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S233 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y251 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T332 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K381 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 21572392 | ||
| K383 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 21572392 | ||
| S412 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y413 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y440 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K521 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S656 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K739 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9HCE7 (SMURF1) | T145 | Q5VWQ8 (DAB2IP) | unknown | eFIP | 27036023 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:Q9HCE7-2 (hSMURF1/iso:Short) | Interaction | PRO | 11278251, 16299379 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y69 | H69 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S148 | L148 | Biomuta | [ cosmic ] | |
| T223 | K223 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T223 | M223 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| K521 | T521 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
