iPTMnet Report for Q9HCE6 (ARHGEF10L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCE6 / ARGAL_HUMAN
Protein Name Rho guanine nucleotide exchange factor 10-like protein
Gene Name Name: ARHGEF10L
Synonyms:GRINCHGEF,KIAA1626;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCE6
DAG View
PRO Name Rho guanine nucleotide exchange factor 10-like protein (human)
Definition A Rho guanine nucleotide exchange factor 10-like protein that is encoded in the genome of human.
Short Label hARHGEF10L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCE6 (ARHGEF10L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y131 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
K260 Acetylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus   UniProt 24275569
S311 Phosphorylation PhosphoSitePlus
K431 Acetylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
K596 Sumoylation PhosphoSitePlus
K600 Sumoylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
S791 Phosphorylation IEDB   PhosphoSitePlus 27869121
S796 Phosphorylation PhosphoSitePlus
K1100 Ubiquitination PhosphoSitePlus
Y1175 Phosphorylation PhosphoSitePlus
S1179 Phosphorylation PhosphoSitePlus
S1189 Phosphorylation PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y131 C131 Biomuta DOID:363 / uterine cancer [ icgc ]
S138 I138 Biomuta DOID:3571 / liver cancer [ cosmic ]
S181 L181 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S205 P205 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S281 L281 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S311 N311 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K431 E431 Biomuta DOID:4159 / skin cancer [ cosmic ]
K431 N431 Biomuta DOID:263 / kidney cancer [ cosmic ]
S532 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S630 L630 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S630 P630 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S636 F636 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S791 C791 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1100 M1100 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1189 F1189 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]