iPTMnet Report for Q9HCE5 (METTL14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCE5 / MET14_HUMAN
Protein Name N6-adenosine-methyltransferase non-catalytic subunit
Gene Name Name: METTL14
Synonyms:KIAA1627;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCE5
DAG View
PRO Name N6-adenosine-methyltransferase non-catalytic subunit (human)
Definition An N6-adenosine-methyltransferase non-catalytic subunit that is encoded in the genome of human.
Short Label hMETTL14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCE5 (METTL14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
T272 Phosphorylation HPRD   PhosphoSitePlus 20068231
K278 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus   UniProt 27281194, 29348140, 24275569
R442 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y100 H100 Biomuta DOID:4159 / skin cancer [ cosmic ]
K156 M156 Biomuta DOID:1324 / lung cancer [ cosmic ]
S399 L399 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]