iPTMnet Report for Q9HCC6 (HES4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCC6 / HES4_HUMAN
Protein Name Transcription factor HES-4
Gene Name Name: HES4
Synonyms:BHLHB42;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCC6
DAG View
PRO Name transcription factor HES-4 (human)
Definition A transcription factor HES-4 that is encoded in the genome of human.
Short Label hHES4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCC6 (HES4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Acetylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 W12 Biomuta DOID:1324 / lung cancer [ cosmic ]
S70 P70 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]