iPTMnet Report for Q9HCC0 (MCCC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HCC0 / MCCB_HUMAN
Protein Name Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial precursor
Gene Name Name: MCCC2
Synonyms:MCCB;
Organism Homo sapiens (Human)

PRO ID PR:Q9HCC0
DAG View
PRO Name methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (human)
Definition A methylcrotonoyl-CoA carboxylase beta chain, mitochondrial that is encoded in the genome of human. The human MCCC2 gene contains 17 exons, and maps to the chromosomal location 5q12-q13.
Short Label hMCCC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HCC0 (MCCC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K50 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
C267 S-Nitrosylation dbSNO 26338901
K269 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
K383 Acetylation PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K512 Acetylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
T537 Phosphorylation PhosphoSitePlus
R562 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S471 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K64 Q64 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R188 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K420 R420 Biomuta [ cosmic ]
K424 N424 Biomuta DOID:1324 / lung cancer [ cosmic ]
S471 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
T484 M484 Biomuta DOID:3571 / liver cancer [ cosmic ]
T484 R484 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y520 H520 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R562 S562 Biomuta DOID:4159 / skin cancer [ cosmic ]