iPTMnet Report for Q9HC98 (NEK6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HC98 / NEK6_HUMAN
Protein Name Serine/threonine-protein kinase Nek6
Gene Name Name: NEK6
Organism Homo sapiens (Human)

PRO ID PR:Q9HC98
DAG View
PRO Name serine/threonine-protein kinase Nek6 (human)
Definition A serine/threonine-protein kinase Nek6 that is encoded in the genome of human.
Short Label hNEK6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HC98 (NEK6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T35 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus   UniProt 12840024
S41 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
C64 Methylation IEDB 31844290
K85 Ubiquitination PhosphoSitePlus
C90 Methylation IEDB 31844290
K92 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
T202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12840024
S206 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 12840024, 20873783, ...21320329, 21454704, 12101123, 23186163
S206 Phosphorylation Q8TD19 (NEK9) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 21454704, 12840024, 12101123
T210 Phosphorylation PhosphoSitePlus   UniProt 17512906
Y212 Phosphorylation PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
C258 Methylation IEDB 31844290
K277 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T35 Phosphorylation HPRD 20068231
S206 Phosphorylation HPRD 12840024
S206 Phosphorylation Q8TD19 (NEK9) HPRD 12840024
Site PTM Type PTM Enzyme Score Source PMID
T69 Phosphorylation HPRD 20068231


Q9HC98 (NEK6) as PTM Enzyme



Substrate Site Score Source PMID
O00141 (SGK1) S377 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 12023960
O00141-1 (SGK1) S422 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 12023960, 10191262
P0DMV8 (HSPA1A) T66 PhosphoSitePlus 25940345
P14859 (POU2F1) S335 neXtProt 21897860
P23443 (RPS6KB1) S53 PhosphoSitePlus 12023960
P23443 (RPS6KB1) S403 PhosphoSitePlus 12023960
P23443 (RPS6KB1) T412 neXtProt   PhosphoSitePlus 12023960, 11516946
P40763 (STAT3) S727 neXtProt   PhosphoSitePlus 20595392
P50613 (CDK7) S161 neXtProt   PhosphoSitePlus 12023960
P52732 (KIF11) S1033 neXtProt 19001501
P52948-2 (NUP98) S591 PhosphoSitePlus 21335236
P52948 (NUP98) S608 neXtProt 21335236
P52948-2 (NUP98) S822 PhosphoSitePlus 21335236
P52948 (NUP98) S839 neXtProt 21335236
Q05586 (GRIN1) S890 neXtProt   PhosphoSitePlus 12023960
Q08345 (DDR1) S788 neXtProt   PhosphoSitePlus 12023960
Q08999 (RBL2) S659 neXtProt   PhosphoSitePlus 12023960
Q96AP0 (ACD) S169 Signor 27396482


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048575 (hNEK6/Phos:1) pS206 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 L41 Biomuta DOID:4159 / skin cancer [ cosmic ]
C90 S90 Biomuta DOID:1324 / lung cancer [ cosmic ]
S165 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K187 Q187 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T201 N201 Biomuta DOID:5041 / esophageal cancer [ cosmic ]