iPTMnet Report for Q9HC38 (GLOD4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HC38 / GLOD4_HUMAN
Protein Name Glyoxalase domain-containing protein 4
Gene Name Name: GLOD4
Synonyms:C17orf25;ORFNames:CGI-150,My027;
Organism Homo sapiens (Human)

PRO ID PR:Q9HC38
DAG View
PRO Name glyoxalase domain-containing protein 4 (human)
Definition A glyoxalase domain-containing protein 4 that is encoded in the genome of human.
Short Label hGLOD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HC38 (GLOD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Acetylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K181 Acetylation PhosphoSitePlus
C197 S-Nitrosylation dbSNO 24105792
K198 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
C221 S-Nitrosylation dbSNO 19483679, 24105792
K224 Ubiquitination PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
C269 Methylation IEDB 31844290
S280 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation PhosphoSitePlus
Y23 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
R33 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 E12 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y23 C23 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K181 R181 Biomuta DOID:1324 / lung cancer [ cosmic ]
K224 N224 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K224 Q224 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S246 R246 Biomuta DOID:3571 / liver cancer [ cosmic ]
S287 R287 Biomuta DOID:9256 / colorectal cancer [ cosmic ]