iPTMnet Report for Q9HC29 (NOD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HC29 / NOD2_HUMAN
Protein Name Nucleotide-binding oligomerization domain-containing protein 2
Gene Name Name: NOD2
Synonyms:CARD15;
Organism Homo sapiens (Human)

PRO ID PR:Q9HC29
DAG View
PRO Name nucleotide-binding oligomerization domain-containing protein 2 (human)
Definition A nucleotide-binding oligomerization domain-containing protein 2 that is encoded in the genome of human.
Short Label hNOD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HC29 (NOD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T189 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
C693 Methylation IEDB 31844290
K717 Acetylation PhosphoSitePlus
K731 Acetylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
Y747 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
T1022 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T189 M189 Biomuta DOID:1324 / lung cancer [ cosmic ]
S402 F402 Biomuta DOID:4159 / skin cancer [ cosmic ]
S477 L477 Biomuta DOID:1324 / lung cancer [ cosmic ]
S493 Y493 Biomuta DOID:1324 / lung cancer [ cosmic ]
C693 F693 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
C693 Y693 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K731 R731 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y747 F747 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]