iPTMnet Report for Q9HBM1 (SPC25)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HBM1 / SPC25_HUMAN
Protein Name Kinetochore protein Spc25
Gene Name Name: SPC25
Synonyms:SPBC25;ORFNames:AD024;
Organism Homo sapiens (Human)

PRO ID PR:Q9HBM1
DAG View
PRO Name kinetochore protein Spc25 (human)
Definition A kinetochore protein Spc25 that is encoded in the genome of human.
Short Label hSPC25
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HBM1 (SPC25) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
S12 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K19 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K107 Sumoylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K19 Q19 Biomuta DOID:4159 / skin cancer [ cosmic ]
K107 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K203 N203 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]