Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HBL0 / TENS1_HUMAN
Protein Name Tensin-1
Gene Name Name: TNS1
Synonyms:TNS;
Organism Homo sapiens (Human)

PRO ID PR:Q9HBL0
DAG View
PRO Name tensin-1 (human)
Definition A tensin-1 that is encoded in the genome of human.
Short Label hTNS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HBL0 (TNS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
Y327 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T329 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 24275569, 18220336
Y339 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S343 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y366 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 24275569
S374 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus   UniProt 24275569
T379 Phosphorylation PhosphoSitePlus   UniProt 24275569
S390 Phosphorylation PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus   UniProt 24275569
K437 Ubiquitination PhosphoSitePlus
S445 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y458 Phosphorylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
Y591 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S619 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S621 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S623 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
T688 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus   UniProt 20068231
S708 Phosphorylation PhosphoSitePlus
T711 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S733 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S742 Phosphorylation PhosphoSitePlus
S746 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S756 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y766 Phosphorylation PhosphoSitePlus
S769 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 18220336
S772 Phosphorylation PhosphoSitePlus
T775 Phosphorylation PhosphoSitePlus
R781 Methylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
Y793 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y796 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y798 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
T843 Phosphorylation PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S858 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T860 Phosphorylation PhosphoSitePlus   UniProt 24275569
S899 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y903 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 24275569
S907 Phosphorylation PhosphoSitePlus   UniProt 24275569
T911 Phosphorylation PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
T959 Phosphorylation PhosphoSitePlus
S960 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S967 Phosphorylation PhosphoSitePlus   UniProt 24275569
S971 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
Y1025 Phosphorylation PhosphoSitePlus
S1046 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1048 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
Y1055 Phosphorylation PhosphoSitePlus
T1105 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087, 18220336
T1107 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 24275569, 18220336
S1126 Phosphorylation PhosphoSitePlus
Y1131 Phosphorylation PhosphoSitePlus
S1133 Phosphorylation phospho.ELM 18669648
S1135 Phosphorylation PhosphoSitePlus
T1139 Phosphorylation PhosphoSitePlus
S1142 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
Y1144 Phosphorylation PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus
S1146 Phosphorylation PhosphoSitePlus
Y1149 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 18669648
S1150 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1156 Phosphorylation PhosphoSitePlus
S1157 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S1160 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1167 Phosphorylation PhosphoSitePlus
T1173 Phosphorylation PhosphoSitePlus
S1177 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
T1184 Phosphorylation PhosphoSitePlus
T1189 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1192 Phosphorylation PhosphoSitePlus   UniProt 18088087, 18220336, 18669648, ...24275569, 20068231
S1209 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
S1243 Phosphorylation PhosphoSitePlus
Y1254 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation PhosphoSitePlus
T1265 Phosphorylation PhosphoSitePlus
T1266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1269 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 18220336, 18669648, ...23186163, 20068231
S1271 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1297 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
S1309 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1314 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 18220336, 24275569, ...23186163, 20068231
Y1323 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y1326 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 18220336
S1327 Phosphorylation PhosphoSitePlus
T1328 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
T1335 Phosphorylation PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus
S1340 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
Y1345 Phosphorylation PhosphoSitePlus
S1349 Phosphorylation PhosphoSitePlus
S1352 Phosphorylation PhosphoSitePlus
Y1359 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
S1381 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 18088087, ...24275569
T1383 Phosphorylation PhosphoSitePlus
S1393 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1400 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1404 Phosphorylation PhosphoSitePlus   RLIMS-P 26216473
T1406 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
S1417 Phosphorylation PhosphoSitePlus
S1420 Phosphorylation PhosphoSitePlus
S1421 Phosphorylation PhosphoSitePlus
S1423 Phosphorylation PhosphoSitePlus
S1426 Phosphorylation PhosphoSitePlus
Y1440 Phosphorylation PhosphoSitePlus
S1441 Phosphorylation PhosphoSitePlus
S1446 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K1454 Ubiquitination PhosphoSitePlus
Y1462 Phosphorylation PhosphoSitePlus
S1490 Phosphorylation PhosphoSitePlus
S1492 Phosphorylation PhosphoSitePlus
T1509 Phosphorylation PhosphoSitePlus
S1579 Phosphorylation PhosphoSitePlus
K1580 Ubiquitination PhosphoSitePlus
S1583 Phosphorylation PhosphoSitePlus
S1588 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1589 Phosphorylation PhosphoSitePlus
T1665 Phosphorylation PhosphoSitePlus
T1667 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y327 Phosphorylation HPRD 18083107
Y339 Phosphorylation HPRD 18083107
Y366 Phosphorylation HPRD 18083107
S445 Phosphorylation HPRD 18669648
S619 Phosphorylation HPRD 20166139, 18669648
S621 Phosphorylation HPRD 20166139, 18669648
S701 Phosphorylation HPRD 20068231
S764 Phosphorylation HPRD 20166139
S769 Phosphorylation HPRD 18669648
Y796 Phosphorylation HPRD 18083107
S858 Phosphorylation HPRD 20166139
T860 Phosphorylation HPRD 20166139
S899 Phosphorylation HPRD 20166139
Y903 Phosphorylation HPRD 18083107
T1107 Phosphorylation HPRD 18088087
S1133 Phosphorylation HPRD 18669648
Y1149 Phosphorylation HPRD 18083107, 18669648
S1157 Phosphorylation HPRD 18669648
S1160 Phosphorylation HPRD 18669648
S1177 Phosphorylation HPRD 17322306, 18767875, 18669648, ...20166139, 20068231
T1266 Phosphorylation HPRD 18669648, 20068231
S1269 Phosphorylation HPRD 17322306, 18767875, 18669648, ...18088087, 20068231
S1271 Phosphorylation HPRD 20068231
S1294 Phosphorylation HPRD 20068231
S1297 Phosphorylation HPRD 17081983, 20068231
S1299 Phosphorylation HPRD 20068231
S1314 Phosphorylation HPRD 18088087, 20068231
Y1323 Phosphorylation HPRD 18083107
Y1326 Phosphorylation HPRD 18083107
S1381 Phosphorylation HPRD 18767875, 18669648, 18088087, ...20068231
T1383 Phosphorylation HPRD 20068231
Y1404 Phosphorylation HPRD 18083107
S1446 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T68 M68 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S92 N92 Biomuta DOID:1909 / melanoma [ cosmic ]
S92 R92 Biomuta DOID:3571 / liver cancer [ icgc ]
Y210 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K249 N249 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S257 R257 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S330 Y330 Biomuta DOID:363 / uterine cancer [ tcga ]
T357 M357 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S364 C364 Biomuta DOID:3571 / liver cancer [ tcga ]
S471 L471 Biomuta DOID:1909 / melanoma [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
S538 Y538 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S547 F547 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T575 M575 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S619 T619 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S623 L623 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:3070 / malignant glioma [ cosmic, icgc ] DOID:2531 / hematologic cancer [ tcga ]
S623 P623 Biomuta DOID:3571 / liver cancer [ icgc ]
S649 L649 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:1612 / breast cancer [ cosmic ]
S681 I681 Biomuta DOID:10534 / stomach cancer [ icgc ]
S681 G681 Biomuta DOID:1324 / lung cancer [ cosmic ]
S701 F701 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S701 Y701 Biomuta DOID:1324 / lung cancer [ cosmic ]
S708 Y708 Biomuta DOID:3571 / liver cancer [ icgc ]
T711 K711 Biomuta DOID:3571 / liver cancer [ icgc ]
S731 T731 Biomuta DOID:1324 / lung cancer [ icgc ]
S731 F731 Biomuta DOID:1909 / melanoma [ tcga ]
S762 P762 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S772 L772 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R781 W781 Biomuta DOID:10534 / stomach cancer [ icgc ]
R781 Q781 Biomuta DOID:363 / uterine cancer [ tcga ]
S783 F783 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y796 C796 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S849 L849 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S907 P907 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ]
S912 Y912 Biomuta DOID:3571 / liver cancer [ icgc ]
S920 F920 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S948 R948 Biomuta DOID:3571 / liver cancer [ icgc ]
S960 C960 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S962 R962 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S967 C967 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S971 F971 Biomuta DOID:1909 / melanoma [ tcga ]
T1105 M1105 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S1119 N1119 Biomuta DOID:10534 / stomach cancer [ tcga ]
S1124 N1124 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y1144 * Biomuta DOID:3571 / liver cancer [ icgc ]
T1173 M1173 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T1173 K1173 Biomuta DOID:3571 / liver cancer [ icgc ]
T1173 S1173 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1209 N1209 Biomuta DOID:363 / uterine cancer [ tcga ]
S1299 N1299 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1327 C1327 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1352 P1352 Biomuta DOID:363 / uterine cancer [ tcga ]
S1381 R1381 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T1383 K1383 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1417 R1417 Biomuta DOID:3571 / liver cancer [ icgc ]
Y1440 H1440 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]