iPTMnet Report for Q9HBL0 (TNS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HBL0 / TENS1_HUMAN
Protein Name Tensin-1
Gene Name Name: TNS1
Synonyms:TNS;
Organism Homo sapiens (Human)

PRO ID PR:Q9HBL0
DAG View
PRO Name tensin-1 (human)
Definition A tensin-1 that is encoded in the genome of human.
Short Label hTNS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HBL0 (TNS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S463 Phosphorylation UniProt 24275569
S489 Phosphorylation UniProt 24275569
Y491 Phosphorylation UniProt 24275569
S503 Phosphorylation UniProt 24275569
T504 Phosphorylation UniProt 24275569
S558 Phosphorylation UniProt 24275569
S619 Phosphorylation phospho.ELM 18669648
S746 Phosphorylation phospho.ELM   UniProt 23186163, 18220336
S826 Phosphorylation UniProt 20068231
S858 Phosphorylation phospho.ELM 18220336
S889 Phosphorylation UniProt 24275569
S894 Phosphorylation UniProt 24275569
S919 Phosphorylation UniProt 24275569
T985 Phosphorylation UniProt 24275569
S1024 Phosphorylation UniProt 23186163, 24275569
Y1028 Phosphorylation UniProt 24275569
S1032 Phosphorylation UniProt 24275569
S1088 Phosphorylation UniProt 23186163, 24275569
S1092 Phosphorylation UniProt 24275569
T1156 O-Glycosylation GlyGen   UniProt 20798394
S1228 Phosphorylation UniProt 24275569
S1271 O-Glycosylation GlyGen   UniProt 20798394
S1281 Phosphorylation UniProt 18669648, 23186163, 20068231, ...24275569
T1293 Phosphorylation UniProt 20068231
S1296 Phosphorylation UniProt 18669648, 18088087, 20068231, ...24275569, 18220336
T1370 Phosphorylation UniProt 18669648
S1373 Phosphorylation UniProt 18669648, 23186163, 20068231
S1398 Phosphorylation UniProt 20068231
S1413 Phosphorylation UniProt 24275569
S1418 Phosphorylation UniProt 18088087, 23186163, 20068231, ...24275569, 18220336
S1441 O-Glycosylation GlyGen 30379171, 33214551, 28657654, ...34019948
S1485 Phosphorylation UniProt 18669648, 23186163, 24275569
S1497 Phosphorylation UniProt 24275569
S1504 Phosphorylation UniProt 23186163
S1550 Phosphorylation UniProt 18669648
S1692 Phosphorylation UniProt 24275569
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
Y327 Phosphorylation HPRD   PhosphoSitePlus 18083107
T329 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
Y339 Phosphorylation HPRD   PhosphoSitePlus 18083107
S343 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation HPRD   PhosphoSitePlus 18083107
S374 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S445 Phosphorylation HPRD   PhosphoSitePlus 18669648
Y458 Phosphorylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
Y591 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S619 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18669648
S621 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18669648
S623 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
T688 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
S701 Phosphorylation HPRD   PhosphoSitePlus 20068231
S708 Phosphorylation PhosphoSitePlus
T711 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S764 Phosphorylation HPRD   PhosphoSitePlus 20166139
Y766 Phosphorylation PhosphoSitePlus
S769 Phosphorylation HPRD   PhosphoSitePlus 18669648
S772 Phosphorylation PhosphoSitePlus
T775 Phosphorylation PhosphoSitePlus
R781 Methylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
Y793 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
Y796 Phosphorylation HPRD   PhosphoSitePlus 18083107
Y798 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
T843 Phosphorylation PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S858 Phosphorylation HPRD   PhosphoSitePlus 20166139
T860 Phosphorylation HPRD   PhosphoSitePlus 20166139
S899 Phosphorylation HPRD   PhosphoSitePlus 20166139
Y903 Phosphorylation HPRD   PhosphoSitePlus 18083107
S907 Phosphorylation PhosphoSitePlus
T911 Phosphorylation PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
T959 Phosphorylation PhosphoSitePlus
S960 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus
S967 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
Y1025 Phosphorylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
Y1055 Phosphorylation PhosphoSitePlus
T1105 Phosphorylation PhosphoSitePlus
T1107 Phosphorylation HPRD   PhosphoSitePlus 18088087
S1113 Phosphorylation PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
Y1131 Phosphorylation PhosphoSitePlus
S1133 Phosphorylation HPRD 18669648
S1135 Phosphorylation PhosphoSitePlus
T1139 Phosphorylation PhosphoSitePlus
S1142 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
Y1144 Phosphorylation PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus
S1146 Phosphorylation PhosphoSitePlus
Y1149 Phosphorylation HPRD   PhosphoSitePlus 18083107, 18669648
S1150 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
S1156 Phosphorylation PhosphoSitePlus
S1157 Phosphorylation HPRD   PhosphoSitePlus 18669648
S1160 Phosphorylation HPRD   PhosphoSitePlus 18669648
S1167 Phosphorylation PhosphoSitePlus
T1173 Phosphorylation PhosphoSitePlus
S1177 Phosphorylation HPRD   PhosphoSitePlus 18767875, 17322306, 18669648, ...20166139, 20068231
T1184 Phosphorylation PhosphoSitePlus
T1189 Phosphorylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
S1243 Phosphorylation PhosphoSitePlus
Y1254 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation PhosphoSitePlus
T1265 Phosphorylation PhosphoSitePlus
T1266 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S1269 Phosphorylation HPRD   PhosphoSitePlus 18088087, 18767875, 17322306, ...18669648, 20068231
S1271 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1294 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1297 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S1299 Phosphorylation HPRD 20068231
S1307 Phosphorylation PhosphoSitePlus
S1309 Phosphorylation PhosphoSitePlus
S1314 Phosphorylation HPRD   PhosphoSitePlus 18088087, 20068231
Y1323 Phosphorylation HPRD   PhosphoSitePlus 18083107
Y1326 Phosphorylation HPRD   PhosphoSitePlus 18083107
S1327 Phosphorylation PhosphoSitePlus
T1328 Phosphorylation PhosphoSitePlus
T1335 Phosphorylation PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus
S1340 Phosphorylation PhosphoSitePlus
S1341 Phosphorylation PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
Y1345 Phosphorylation PhosphoSitePlus
S1349 Phosphorylation PhosphoSitePlus
S1352 Phosphorylation PhosphoSitePlus
Y1359 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
S1381 Phosphorylation HPRD   PhosphoSitePlus 18767875, 18669648, 18088087, ...20068231
T1383 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1393 Phosphorylation PhosphoSitePlus
S1400 Phosphorylation PhosphoSitePlus
Y1404 Phosphorylation HPRD   PhosphoSitePlus 18083107
T1406 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
S1417 Phosphorylation PhosphoSitePlus
S1420 Phosphorylation PhosphoSitePlus
S1421 Phosphorylation PhosphoSitePlus
S1423 Phosphorylation PhosphoSitePlus
S1426 Phosphorylation PhosphoSitePlus
Y1440 Phosphorylation PhosphoSitePlus
S1441 Phosphorylation PhosphoSitePlus
S1446 Phosphorylation HPRD   PhosphoSitePlus 18669648
K1454 Ubiquitination PhosphoSitePlus
Y1462 Phosphorylation PhosphoSitePlus
S1490 Phosphorylation PhosphoSitePlus
S1492 Phosphorylation PhosphoSitePlus
T1509 Phosphorylation PhosphoSitePlus
S1579 Phosphorylation PhosphoSitePlus
K1580 Ubiquitination PhosphoSitePlus
S1583 Phosphorylation PhosphoSitePlus
S1588 Phosphorylation PhosphoSitePlus
T1589 Phosphorylation PhosphoSitePlus
T1665 Phosphorylation PhosphoSitePlus
T1667 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T68 M68 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S92 N92 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y210 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K249 N249 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S257 R257 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y327 * Biomuta [ cosmic ]
S330 Y330 Biomuta DOID:363 / uterine cancer [ icgc ]
T357 M357 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S364 C364 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y366 C366 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S390 L390 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S406 L406 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S471 L471 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
S538 Y538 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S547 F547 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T575 M575 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S607 C607 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S619 T619 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S623 L623 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S623 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S649 L649 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S681 G681 Biomuta DOID:1324 / lung cancer [ cosmic ]
S701 Y701 Biomuta DOID:1324 / lung cancer [ cosmic ]
S701 F701 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S708 C708 Biomuta DOID:1324 / lung cancer [ cosmic ]
S731 T731 Biomuta DOID:1324 / lung cancer [ icgc ]
S731 F731 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S733 N733 Biomuta DOID:4159 / skin cancer [ cosmic ]
S762 F762 Biomuta DOID:4159 / skin cancer [ cosmic ]
S762 A762 Biomuta DOID:4159 / skin cancer [ cosmic ]
S762 P762 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S772 L772 Biomuta DOID:3571 / liver cancer [ cosmic ]
R781 Q781 Biomuta DOID:363 / uterine cancer [ icgc ]
S783 F783 Biomuta DOID:1324 / lung cancer [ cosmic ]
S786 F786 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y796 C796 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S849 L849 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S858 F858 Biomuta DOID:4159 / skin cancer [ cosmic ]
S907 P907 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S920 F920 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S926 A926 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S960 C960 Biomuta DOID:10283 / prostate cancer [ icgc ]
S967 C967 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S971 F971 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1105 M1105 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S1117 L1117 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1119 N1119 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1124 N1124 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1145 N1145 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1150 A1150 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1173 M1173 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1173 S1173 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1299 N1299 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1327 F1327 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1327 C1327 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1352 P1352 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1381 R1381 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T1383 K1383 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1413 L1413 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1417 R1417 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1440 H1440 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1492 F1492 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1579 L1579 Biomuta DOID:2998 / testicular cancer [ cosmic ]
T1665 I1665 Biomuta DOID:4159 / skin cancer [ cosmic ]