Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HBH9 / MKNK2_HUMAN
Protein Name MAP kinase-interacting serine/threonine-protein kinase 2
Gene Name Name: MKNK2
Synonyms:GPRK7,MNK2;
Organism Homo sapiens (Human)

PRO ID PR:Q9HBH9
DAG View
PRO Name MAP kinase-interacting serine/threonine-protein kinase 2 (human)
Definition A MAP kinase-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human.
Short Label hMKNK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HBH9 (MKNK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Sumoylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S43 Phosphorylation P28482 (MAPK1) neXtProt 11154262
T72 Phosphorylation PhosphoSitePlus
S74 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 32170339, 11154262
S76 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K207 Sumoylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S220 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 11154262
K223 Ubiquitination PhosphoSitePlus
T244 Phosphorylation UniProt 11463832
T249 Phosphorylation UniProt 11463832
K326 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
T379 Phosphorylation P28482 (MAPK1) neXtProt   UniProt 11463832, 11154262
K390 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S440 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 11154262
S442 Phosphorylation PhosphoSitePlus
S452 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   UniProt 23186163, 11154262
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation HPRD 11154262
S74 Phosphorylation HPRD 18669648
S220 Phosphorylation HPRD 11154262
T379 Phosphorylation HPRD 11154262
S437 Phosphorylation HPRD 11154262
S440 Phosphorylation HPRD 11154262
S452 Phosphorylation HPRD 18691976, 19664994, 11154262
S454 Phosphorylation HPRD 11154262
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation HPRD 11154262
S74 Phosphorylation HPRD 18669648
S220 Phosphorylation HPRD 11154262
T379 Phosphorylation HPRD 11154262


Q9HBH9 (MKNK2) as PTM Enzyme



Substrate Site Score Source PMID
O43597 (SPRY2) S112 PhosphoSitePlus 19864419
O43597 (SPRY2) S121 PhosphoSitePlus 19864419
P06730 (EIF4E) S209 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 20823271, 11463832, 16540463, ...20927323, 20722422, 17724079, 12897141, 11723111, 11154262, 9155017
P23246 (SFPQ) S8 neXtProt   PhosphoSitePlus 17965020
P23246 (SFPQ) S283 neXtProt   PhosphoSitePlus 17965020
Q15149 (PLEC) S4642 PhosphoSitePlus 23843618


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K390 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S437 Y437 Biomuta DOID:1612 / breast cancer [ cosmic ]
S452 G452 Biomuta DOID:3571 / liver cancer [ tcga ]
S454 Y454 Biomuta DOID:3571 / liver cancer [ icgc ]