iPTMnet Report for Q9HBH9 (MKNK2)
Protein Information
| UniProt AC / UniProt ID | Q9HBH9 / MKNK2_HUMAN |
| Protein Name | MAP kinase-interacting serine/threonine-protein kinase 2 |
| Gene Name | Name: MKNK2 Synonyms:GPRK7,MNK2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9HBH9 |
| PRO Name | MAP kinase-interacting serine/threonine-protein kinase 2 (human) |
| Definition | A MAP kinase-interacting serine/threonine-protein kinase 2 that is encoded in the genome of human. |
| Short Label | hMKNK2 |
| Category | organism-gene |
DAG ViewQ9HBH9 (MKNK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K5 | Sumoylation | score1 | PhosphoSitePlus | |||
| S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S43 | Phosphorylation | P28482 (MAPK1) | score2 | neXtProt | 11154262 | |
| T72 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S74 | Phosphorylation | P28482 (MAPK1) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 18669648, 11154262 | |
| S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C101 | Methylation | score1 | IEDB | 31844290 | ||
| S124 | Phosphorylation | score1 | IEDB | 35494241 | ||
| C136 | Methylation | score1 | IEDB | 31844290 | ||
| K173 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K207 | Sumoylation | score1 | PhosphoSitePlus | |||
| K207 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C213 | Methylation | score1 | IEDB | 31844290 | ||
| S220 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 11154262 | |
| K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T244 | Phosphorylation | score2 | UniProt | 11463832 | ||
| T249 | Phosphorylation | score2 | UniProt | 11463832 | ||
| K326 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K342 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K347 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T379 | Phosphorylation | P28482 (MAPK1) | score4 | neXtProt UniProt | 11463832, 11154262 | |
| K390 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S437 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S440 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 11154262 | |
| S442 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S452 | Phosphorylation | P28482 (MAPK1) | score4 | neXtProt PhosphoSitePlus UniProt | 23186163, 11154262 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S27 | Phosphorylation | score1 | HPRD | 11154262 | ||
| S74 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S220 | Phosphorylation | score1 | HPRD | 11154262 | ||
| T379 | Phosphorylation | score1 | HPRD | 11154262 | ||
| S437 | Phosphorylation | score1 | HPRD | 11154262 | ||
| S440 | Phosphorylation | score1 | HPRD | 11154262 | ||
| S452 | Phosphorylation | score2 | HPRD | 18691976, 19664994, 11154262 | ||
| S454 | Phosphorylation | score1 | HPRD | 11154262 |
Q9HBH9 (MKNK2) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O43597 (SPRY2) | S112 | score2 | PhosphoSitePlus | 19864419 | |
| O43597 (SPRY2) | S121 | score2 | PhosphoSitePlus | 19864419 | |
| P06730 (EIF4E) | S209 | score4 | HPRD neXtProt PhosphoSitePlus RLIMS-P+ Signor | 20823271, 11463832, 11723111, ... | |
| P23246 (SFPQ) | S8 | score3 | neXtProt PhosphoSitePlus | 17965020 | |
| P23246 (SFPQ) | S283 | score3 | neXtProt PhosphoSitePlus | 17965020 | |
| Q15149 (PLEC) | S4642 | score2 | PhosphoSitePlus | 23843618 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S76 | L76 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] | |
| S220 | C220 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| K342 | N342 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K390 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S437 | Y437 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S452 | G452 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] |
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