iPTMnet Report for Q9HBD1 (RC3H2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HBD1 / RC3H2_HUMAN
Protein Name Roquin-2
Gene Name Name: RC3H2
Synonyms:MNAB,RNF164;
Organism Homo sapiens (Human)

PRO ID PR:Q9HBD1
DAG View
PRO Name roquin-2 (human)
Definition A roquin-2 that is encoded in the genome of human.
Short Label hRC3H2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HBD1 (RC3H2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S120 Phosphorylation IEDB   PhosphoSitePlus 32387766
S250 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
T468 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...31637018, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 35289036, 30620550, 28657654, 29237092
T470 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
T471 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...31637018, 32574038, 32938750, 34019948, 30059200, 35132862, 31492838, 35289036, 30620550, 28657654, 29237092
T472 O-Glycosylation GlyGen 33214551, 35138101, 35254053, ...31637018, 32574038, 32938750, 34019948, 30059200, 35132862, 31492838, 35289036, 30620550, 28657654, 29237092
S492 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S497 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
T514 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus   UniProt 19690332
T553 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
T561 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S562 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S566 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S566 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus
S593 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...35254053, 31637018, 32574038, 32938750, 34019948, 30059200, 35132862, 31492838, 35289036, 30620550, 28657654, 29237092
R666 Methylation PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus
S726 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
Y736 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation PhosphoSitePlus
T755 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...31637018, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 35289036, 30620550, 28657654, 29237092
T756 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
K768 Methylation PhosphoSitePlus
T769 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S770 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
K778 Ubiquitination PhosphoSitePlus
T801 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S803 Phosphorylation PhosphoSitePlus
T805 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus   UniProt 20068231
S812 Phosphorylation PhosphoSitePlus
T843 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S871 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
T883 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
T887 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
K888 Ubiquitination PhosphoSitePlus
S897 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S903 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S909 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S952 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S960 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...31637018, 32574038, 30059200, 30620550, 35132862, 31492838, 35289036, 35254053, 28657654, 29237092
S982 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus   UniProt 23186163
T984 Phosphorylation PhosphoSitePlus
K996 Ubiquitination PhosphoSitePlus
K1014 Ubiquitination PhosphoSitePlus
S1017 Phosphorylation PhosphoSitePlus
K1031 Ubiquitination PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1168 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T801 Phosphorylation HPRD 20068231
S803 Phosphorylation HPRD 20068231
T805 Phosphorylation HPRD 20068231
S808 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T453 A453 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T472 S472 Biomuta DOID:1324 / lung cancer [ cosmic ]
T561 A561 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S562 L562 Biomuta DOID:1324 / lung cancer [ cosmic ]
R666 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T756 I756 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K875 Q875 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S903 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K1168 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]