iPTMnet Report for Q9HB58 (SP110)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HB58 / SP110_HUMAN
Protein Name Sp110 nuclear body protein
Gene Name Name: SP110
Organism Homo sapiens (Human)

PRO ID PR:Q9HB58
DAG View
PRO Name Sp110 nuclear body protein (human)
Definition An Sp110 nuclear body protein that is encoded in the genome of human.
Short Label hSP110
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HB58 (SP110) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus   UniProt 24275569
S248 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
S269 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
R347 Methylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K394 Acetylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S244 Phosphorylation HPRD 20068231, 18452278
S248 Phosphorylation HPRD 18452278
S256 Phosphorylation HPRD 20058876, 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S244 Phosphorylation HPRD 20068231, 18452278
S248 Phosphorylation HPRD 18452278
S256 Phosphorylation HPRD 20058876, 20068231, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T117 I117 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S150 L150 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S157 N157 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ]
S173 L173 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S248 C248 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S256 Y256 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S269 C269 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S346 W346 Biomuta DOID:4159 / skin cancer [ cosmic ]
S346 P346 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R347 K347 Biomuta DOID:1319 / brain cancer [ cosmic ]
S356 L356 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T367 M367 Biomuta DOID:1324 / lung cancer [ cosmic ]
S534 L534 Biomuta DOID:363 / uterine cancer [ icgc ]
K593 N593 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:1115 / sarcoma [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K593 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]