iPTMnet Report for Q9HB21 (PLEKHA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HB21 / PKHA1_HUMAN
Protein Name Pleckstrin homology domain-containing family A member 1
Gene Name Name: PLEKHA1
Synonyms:TAPP1;
Organism Homo sapiens (Human)

PRO ID PR:Q9HB21
DAG View
PRO Name pleckstrin homology domain-containing family A member 1 (human)
Definition A pleckstrin homology domain-containing family A member 1 that is encoded in the genome of human.
Short Label hPLEKHA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HB21 (PLEKHA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y29 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K173 Methylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
T316 O-Glycosylation GlyGen 29485866, 30379171, 35132862, ...29351928
T322 O-Glycosylation GlyGen 29485866, 30379171, 35132862, ...29351928
S323 O-Glycosylation GlyGen 29485866, 30379171, 35132862, ...29351928
S325 O-Glycosylation GlyGen 29485866, 30379171, 35132862, ...29351928
T326 O-Glycosylation GlyGen 29485866, 30379171, 35132862, ...29351928
S328 O-Glycosylation GlyGen 29485866, 30379171, 35132862, ...29351928
S330 Phosphorylation PhosphoSitePlus
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S335 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
S362 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K369 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y29 Phosphorylation HPRD 19664994
S332 Phosphorylation HPRD 19413330, 18669648
T360 Phosphorylation HPRD 20068231
S362 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S300 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y29 H29 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K72 N72 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T114 R114 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S190 N190 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y212 C212 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K238 E238 Biomuta DOID:363 / uterine cancer [ icgc ]
S332 F332 Biomuta DOID:4159 / skin cancer [ cosmic ]
S332 Y332 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S362 F362 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]