Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HAZ2 / PRD16_HUMAN
Protein Name Histone-lysine N-methyltransferase PRDM16
Gene Name Name: PRDM16
Synonyms:KIAA1675;
Organism Homo sapiens (Human)

PRO ID PR:Q9HAZ2
DAG View
PRO Name histone-lysine N-methyltransferase PRDM16 (human)
Definition A histone-lysine N-methyltransferase PRDM16 that is encoded in the genome of human.
Short Label hPRDM16
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HAZ2 (PRDM16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
K321 Sumoylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
K382 Sumoylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
T611 Phosphorylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
T876 Phosphorylation PhosphoSitePlus
K915 Acetylation PhosphoSitePlus
T974 Phosphorylation PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus
S1089 Phosphorylation PhosphoSitePlus
T1090 Phosphorylation PhosphoSitePlus
K1194 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K568 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 L44 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc ]
Y194 C194 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T421 M421 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T435 A435 Biomuta DOID:1324 / lung cancer [ cosmic ]
S537 I537 Biomuta DOID:1909 / melanoma [ cosmic ]
S586 P586 Biomuta DOID:1793 / pancreatic cancer [ tcga ]