iPTMnet Report for Q9HAZ1 (CLK4)
Protein Information
| UniProt AC / UniProt ID | Q9HAZ1 / CLK4_HUMAN |
| Protein Name | Dual specificity protein kinase CLK4 |
| Gene Name | Name: CLK4 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9HAZ1 |
| PRO Name | dual specificity protein kinase CLK4 (human) |
| Definition | A dual specificity protein kinase CLK4 that is encoded in the genome of human. |
| Short Label | hCLK4 |
| Category | organism-gene |
DAG ViewQ9HAZ1 (CLK4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S17 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S33 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y80 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y89 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S95 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S108 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S111 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S112 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S122 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S123 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S126 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S128 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S136 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18691976, 18669648 | ||
| S138 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18691976, 23186163, 17081983, ... | ||
| K189 | Sumoylation | score1 | PhosphoSitePlus | |||
| K189 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K296 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K302 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y303 | Phosphorylation | score1 | IEDB | 35494241 | ||
| K315 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T328 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S335 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T336 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S339 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18452278 | ||
| T340 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18452278 | ||
| Y343 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K479 | Ubiquitination | score1 | PhosphoSitePlus |
Q9HAZ1 (CLK4) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P00519 (ABL1) | T735 | score3 | neXtProt PhosphoSitePlus Signor | 18794806 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S122 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S128 | L128 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] | |
| S136 | F136 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S136 | C136 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| T328 | M328 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T340 | A340 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
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