iPTMnet Report for Q9HAW4 (CLSPN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HAW4 / CLSPN_HUMAN
Protein Name Claspin
Gene Name Name: CLSPN
Organism Homo sapiens (Human)

PRO ID PR:Q9HAW4
DAG View
PRO Name claspin (human)
Definition A claspin that is encoded in the genome of human.
Short Label hCLSPN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HAW4 (CLSPN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S30 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   Signor 16885021, 16885022, 16934469
S34 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S65 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S67 Phosphorylation O00311 (CDC7) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23598722, 21406692, ...20068231
T69 Phosphorylation phospho.ELM 18669648
S75 Phosphorylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
Y93 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
S110 Phosphorylation O00311 (CDC7) PhosphoSitePlus 23598722
Y120 Phosphorylation PhosphoSitePlus
K187 Acetylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S225 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S232 Phosphorylation PhosphoSitePlus
S260 Phosphorylation O00311 (CDC7) PhosphoSitePlus   UniProt 23598722, 23186163
S265 Phosphorylation O00311 (CDC7) PhosphoSitePlus 23598722
S282 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K338 Acetylation PhosphoSitePlus
S384 O-Glycosylation GlyGen 31373491
K403 Sumoylation PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus   UniProt 23186163
K532 Ubiquitination PhosphoSitePlus
K606 Acetylation PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S704 Phosphorylation O00311 (CDC7) PhosphoSitePlus 23598722
K708 Ubiquitination PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S718 O-Glycosylation GlyGen 30379171, 35254053
S718 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S720 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S721 Phosphorylation O00311 (CDC7) PhosphoSitePlus 23598722
S723 Phosphorylation PhosphoSitePlus   UniProt 20068231
T724 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S731 Phosphorylation PhosphoSitePlus   UniProt 23186163
K734 Ubiquitination PhosphoSitePlus
S744 Phosphorylation O00311 (CDC7) PhosphoSitePlus   UniProt 23598722, 23186163
S750 Phosphorylation PhosphoSitePlus
K756 Acetylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus   UniProt 23186163
S764 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S775 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R795 Methylation PhosphoSitePlus
T797 O-Glycosylation GlyGen 30379171, 35254053
T802 Phosphorylation PhosphoSitePlus
R807 Methylation PhosphoSitePlus
S808 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S810 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S823 Phosphorylation PhosphoSitePlus
K824 Ubiquitination PhosphoSitePlus
K828 Ubiquitination PhosphoSitePlus
S833 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S839 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 19690332
Y843 Phosphorylation PhosphoSitePlus
S846 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17525332, 23186163, ...19690332
Y887 Phosphorylation PhosphoSitePlus
K891 Acetylation PhosphoSitePlus   UniProt 19608861
K891 Ubiquitination PhosphoSitePlus
T916 Phosphorylation O14757 (CHEK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16963448, 18331829
S921 Phosphorylation PhosphoSitePlus
K925 Acetylation PhosphoSitePlus
K925 Ubiquitination PhosphoSitePlus
S945 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P 18331829
K947 Ubiquitination PhosphoSitePlus
T949 Phosphorylation PhosphoSitePlus
S950 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648
S954 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T955 Phosphorylation PhosphoSitePlus
S958 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S959 Phosphorylation PhosphoSitePlus
K963 Ubiquitination PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
S984 Phosphorylation Q9BTU6 (PI4K2A) Signor 18082599
T987 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1018 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1020 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1129 Phosphorylation O00311 (CDC7) PhosphoSitePlus 23598722
S1147 Phosphorylation O00311 (CDC7) PhosphoSitePlus 23598722
S1156 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T1161 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1204 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
T1287 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1289 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
K1292 Sumoylation PhosphoSitePlus
S1310 Phosphorylation PhosphoSitePlus
S1314 Phosphorylation PhosphoSitePlus
S1316 Phosphorylation PhosphoSitePlus
K1321 Sumoylation PhosphoSitePlus
K1321 Ubiquitination PhosphoSitePlus
T1322 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S65 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S67 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
T69 Phosphorylation HPRD 18669648
S75 Phosphorylation HPRD 17081983
S83 Phosphorylation HPRD 19651622, 18669648
Y93 Phosphorylation HPRD 19664994
S225 Phosphorylation HPRD 19651622, 18669648, 20068231
S393 Phosphorylation HPRD 20068231
S516 Phosphorylation HPRD 19651622
S718 Phosphorylation HPRD 20068231
S720 Phosphorylation HPRD 18669648, 20068231
S723 Phosphorylation HPRD 19413330, 20068231
T724 Phosphorylation HPRD 18669648
S762 Phosphorylation HPRD 17081983
S764 Phosphorylation HPRD 17081983
S775 Phosphorylation HPRD 18669648
T802 Phosphorylation HPRD 20068231
S808 Phosphorylation HPRD 19651622, 18669648, 20068231
S810 Phosphorylation HPRD 19413330, 17322306, 18212344, ...19664995, 19651622, 18669648, 20068231
S833 Phosphorylation HPRD 17525332
S839 Phosphorylation HPRD 17525332, 20068231
Y843 Phosphorylation HPRD 20068231
S846 Phosphorylation HPRD 19413330, 17525332, 18669648
T916 Phosphorylation O14757 (CHEK1) HPRD 16963448
S950 Phosphorylation HPRD 19413330, 18077418, 17525332, ...18669648, 20068231
S954 Phosphorylation HPRD 19413330, 18669648, 20068231
T955 Phosphorylation HPRD 19413330
S958 Phosphorylation HPRD 18669648
S959 Phosphorylation HPRD 19413330
S1012 Phosphorylation HPRD 18669648, 18452278
S1018 Phosphorylation HPRD 18669648, 18452278
S1020 Phosphorylation HPRD 18669648, 18452278
S1147 Phosphorylation HPRD 17081983
S1156 Phosphorylation HPRD 18669648, 17081983
T1161 Phosphorylation HPRD 18669648
T1287 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S1289 Phosphorylation HPRD 17322306, 19651622, 18669648, ...19664995, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046739 (hCLSPN/Phos:2) pT916,pS945 PRO
PR:000046740 (hCLSPN/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S67 F67 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y120 N120 Biomuta DOID:1324 / lung cancer [ cosmic ]
S205 R205 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S265 R265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K287 Q287 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S384 L384 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S516 F516 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T639 A639 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S723 Y723 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S764 L764 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R795 C795 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R795 L795 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S808 F808 Biomuta DOID:4159 / skin cancer [ cosmic ]
S839 F839 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y887 H887 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T916 I916 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S954 F954 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S959 L959 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S984 F984 Biomuta DOID:4159 / skin cancer [ cosmic ]
T987 I987 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S1204 N1204 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T1287 A1287 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1289 Y1289 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1310 C1310 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1314 Y1314 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]