Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HAU5 / RENT2_HUMAN
Protein Name Regulator of nonsense transcripts 2
Gene Name Name: UPF2
Synonyms:KIAA1408,RENT2;
Organism Homo sapiens (Human)

PRO ID PR:Q9HAU5
DAG View
PRO Name regulator of nonsense transcripts 2 (human)
Definition A regulator of nonsense transcripts 2 that is encoded in the genome of human.
Short Label hUPF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HAU5 (UPF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
K58 Methylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
T256 Phosphorylation HPRD   PhosphoSitePlus 18452278
T260 Phosphorylation HPRD   PhosphoSitePlus 18452278
T264 Phosphorylation HPRD   PhosphoSitePlus 18452278
S285 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
Y744 Phosphorylation PhosphoSitePlus
T746 Phosphorylation PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
K941 Acetylation PhosphoSitePlus
K964 Acetylation PhosphoSitePlus
Y974 Phosphorylation PhosphoSitePlus
T1088 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...19651622, 20068231
T1093 Phosphorylation HPRD 19651622
T1216 Phosphorylation PhosphoSitePlus
Y1228 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
T1244 Phosphorylation PhosphoSitePlus
K1266 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K103 N103 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K397 Q397 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S513 * Biomuta DOID:1612 / breast cancer [ tcga ]
T597 K597 Biomuta DOID:1115 / sarcoma [ tcga ]
K1266 Q1266 Biomuta DOID:263 / kidney cancer [ tcga ]