iPTMnet Report for Q9HAU4 (SMURF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HAU4 / SMUF2_HUMAN
Protein Name E3 ubiquitin-protein ligase SMURF2
Gene Name Name: SMURF2
Organism Homo sapiens (Human)

PRO ID PR:Q9HAU4
DAG View
PRO Name E3 ubiquitin-protein ligase SMURF2 (human)
Definition An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of human.
Short Label hSMURF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HAU4 (SMURF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K26 Sumoylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
T76 O-Glycosylation GlyGen 25813380
K119 Ubiquitination PhosphoSitePlus   UniProt 31076633
T144 Phosphorylation PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
R232 Methylation PhosphoSitePlus
R234 Methylation PhosphoSitePlus
R237 Methylation PhosphoSitePlus
R239 Methylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus   RLIMS-P 35017630
Y314 Phosphorylation RLIMS-P 31554791
K369 Sumoylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus   RLIMS-P 31554791
Y465 Phosphorylation PhosphoSitePlus
Y499 Phosphorylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9HAU4 (SMURF2) Y314 O15105 (SMAD7) inhibited_association eFIP 31554791


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q9HAU4 (hSMURF2) Interaction PR:Q9Y3C5 (hRNF11) PRO 14755250