iPTMnet Report for Q9HAB8 (PPCS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HAB8 / PPCS_HUMAN
Protein Name Phosphopantothenate--cysteine ligase
Gene Name Name: PPCS
Synonyms:COAB;
Organism Homo sapiens (Human)

PRO ID PR:Q9HAB8
DAG View
PRO Name phosphopantothenate--cysteine ligase (human)
Definition A phosphopantothenate--cysteine ligase that is encoded in the genome of human.
Short Label hPPCS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HAB8 (PPCS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
T45 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation HPRD 20068231
T45 Phosphorylation HPRD 20068231
S229 Phosphorylation HPRD 17322306
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 17322306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S56 F56 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S215 F215 Biomuta DOID:1324 / lung cancer [ cosmic ]
S229 F229 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
K287 I287 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]