iPTMnet Report for Q9H9Y6 (POLR1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H9Y6 / RPA2_HUMAN
Protein Name DNA-directed RNA polymerase I subunit RPA2
Gene Name Name: POLR1B
Organism Homo sapiens (Human)

PRO ID PR:Q9H9Y6
DAG View
PRO Name DNA-directed RNA polymerase I subunit RPA2 (human)
Definition A DNA-directed RNA polymerase I subunit RPA2 that is encoded in the genome of human.
Short Label hPOLR1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H9Y6 (POLR1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Methylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
C103 Methylation IEDB 31844290
Y136 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
C307 Methylation IEDB 31844290
C331 Methylation IEDB 31844290
C361 Methylation IEDB 31844290
K406 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
C471 Methylation IEDB 31844290
C518 Methylation IEDB 31844290
K582 Ubiquitination PhosphoSitePlus
C617 Methylation IEDB 31844290
K693 Methylation PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
K786 Ubiquitination PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus
K863 Methylation PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
K882 Ubiquitination PhosphoSitePlus
C944 Methylation IEDB 31844290
Y971 Phosphorylation PhosphoSitePlus
Y998 Phosphorylation PhosphoSitePlus
Y999 Phosphorylation PhosphoSitePlus
K1009 Ubiquitination PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1083 Ubiquitination PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
Y1118 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T702 Phosphorylation HPRD 20068231
Y703 Phosphorylation HPRD 20068231
Y971 Phosphorylation HPRD 18452278
Y998 Phosphorylation HPRD 18452278
Y999 Phosphorylation HPRD 18452278
Y1118 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K144 N144 Biomuta DOID:1612 / breast cancer [ cosmic ]
K144 M144 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K272 N272 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C331 Y331 Biomuta DOID:363 / uterine cancer [ cosmic ]
K853 E853 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y999 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1051 F1051 Biomuta DOID:4159 / skin cancer [ cosmic ]