Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9H9P8 / L2HDH_HUMAN
Protein Name L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor
Gene Name Name: L2HGDH
Organism Homo sapiens (Human)

DAG View
PRO Name L-2-hydroxyglutarate dehydrogenase, mitochondrial (human)
Definition An L-2-hydroxyglutarate dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hL2HGDH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9H9P8 (L2HGDH) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y102 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus   UniProt 19608861
K155 Ubiquitination PhosphoSitePlus
R165 Methylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K334 Acetylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K155 N155 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S270 G270 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
Y285 C285 Biomuta DOID:10283 / prostate cancer [ cosmic ]