iPTMnet Report for Q9H9B1 (EHMT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H9B1 / EHMT1_HUMAN
Protein Name Histone-lysine N-methyltransferase EHMT1
Gene Name Name: EHMT1
Synonyms:EUHMTASE1,GLP,KIAA1876,KMT1D;
Organism Homo sapiens (Human)

PRO ID PR:Q9H9B1
DAG View
PRO Name histone-lysine N-methyltransferase EHMT1 (human)
Definition A histone-lysine N-methyltransferase, H3 lysine-9 specific 5 that is encoded in the genome of human.
Short Label hEHMT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H9B1 (EHMT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25489052
K22 Sumoylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
T73 Phosphorylation PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
K153 Methylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K234 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
N240 N-Glycosylation GlyGen 26791533
K301 Acetylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
S322 Phosphorylation phospho.ELM 18669648
K327 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K432 Methylation PhosphoSitePlus
K432 Sumoylation PhosphoSitePlus
T433 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus   UniProt 23186163
K439 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
K451 Sumoylation PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus   UniProt 24275569
S497 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K644 Sumoylation PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
K740 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
K890 Ubiquitination PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
Y952 Phosphorylation PhosphoSitePlus
C954 Methylation IEDB 31844290
K968 Ubiquitination PhosphoSitePlus
R1002 Methylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus   UniProt 23186163
C1034 Methylation IEDB 31844290
S1048 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1086 Ubiquitination PhosphoSitePlus
S1276 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N240 N-Glycosylation PRO 26791533
S335 Phosphorylation HPRD 17081983
S336 Phosphorylation HPRD 17081983
S343 Phosphorylation HPRD 18669648, 17081983
S348 Phosphorylation HPRD 17081983
S353 Phosphorylation HPRD 18669648
S395 Phosphorylation HPRD 18452278
T433 Phosphorylation HPRD 19691289
S435 Phosphorylation HPRD 19691289
S448 Phosphorylation HPRD 20068231
S460 Phosphorylation HPRD 20068231
S497 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S38 L38 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
T110 N110 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T164 I164 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T171 M171 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K302 R302 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K303 N303 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K327 E327 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S348 L348 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y952 H952 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K968 N968 Biomuta DOID:4362 / cervical cancer [ icgc ]
R1002 S1002 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]