Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9H981 / ARP8_HUMAN
Protein Name Actin-related protein 8
Gene Name Name: ACTR8
Organism Homo sapiens (Human)

DAG View
PRO Name actin-related protein 8 (human)
Definition An actin-related protein 8 that is encoded in the genome of human.
Short Label hACTR8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9H981 (ACTR8) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K88 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
Y173 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
Y329 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
S412 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 29759113, ...20068231
Y424 Phosphorylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
K447 Acetylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
K507 Methylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S132 Phosphorylation HPRD 17924679, 19691289, 20068231, ...17081983
Y309 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD 20068231
S412 Phosphorylation HPRD 18669648, 20068231
S444 Phosphorylation HPRD 20068231
S562 Phosphorylation HPRD 20068231

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H981 (ACTR8) S412 Q9ULG1 (INO80) unknown eFIP 29759113

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y219 C219 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y329 * Biomuta DOID:3571 / liver cancer [ icgc ]