iPTMnet Report for Q9H8W4 (PLEKHF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H8W4 / PKHF2_HUMAN
Protein Name Pleckstrin homology domain-containing family F member 2
Gene Name Name: PLEKHF2
Synonyms:ZFYVE18;
Organism Homo sapiens (Human)

PRO ID PR:Q9H8W4
DAG View
PRO Name pleckstrin homology domain-containing family F member 2 (human)
Definition A pleckstrin homology domain-containing family F member 2 that is encoded in the genome of human.
Short Label hPLEKHF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H8W4 (PLEKHF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20058876, 23186163
K44 Acetylation PhosphoSitePlus   UniProt 19608861
K44 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
S226 Phosphorylation HPRD   PhosphoSitePlus 20166139
Y227 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
S239 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 19651622, ...18669648, 20068231
S247 Phosphorylation PhosphoSitePlus
S248 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 21406692, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 N16 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K44 E44 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T104 K104 Biomuta DOID:4159 / skin cancer [ cosmic ]
S228 R228 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S248 R248 Biomuta DOID:1324 / lung cancer [ cosmic ]