Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9H7Z6 / KAT8_HUMAN
Protein Name Histone acetyltransferase KAT8
Gene Name Name: KAT8
Organism Homo sapiens (Human)

DAG View
PRO Name histone acetyltransferase KAT8 (human)
Definition A histone acetyltransferase KAT8 that is encoded in the genome of human.
Short Label hKAT8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9H7Z6 (KAT8) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
T14 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K113 Acetylation PhosphoSitePlus   UniProt 19608861
K113 Ubiquitination PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K274 Acetylation Q9H7Z6 (KAT8) PhosphoSitePlus   UniProt 21691301, 22020126, 21217699, ...22547026
S344 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus   UniProt 23186163
K351 Acetylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus   RLIMS-P 24953651
K410 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation HPRD 19413330
S42 Phosphorylation HPRD 19413330
T114 Phosphorylation HPRD 19413330
S348 Phosphorylation HPRD 18691976, 20068231
S456 Phosphorylation HPRD 18691976

Q9H7Z6 (KAT8) as PTM Enzyme

Substrate Site Score Source PMID
Q9H7Z6 (KAT8) K274 UniProt 21217699

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 T37 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y90 C90 Biomuta DOID:263 / kidney cancer [ tcga ]
K113 N113 Biomuta DOID:3571 / liver cancer [ icgc ]
K154 R154 Biomuta DOID:1324 / lung cancer [ tcga ]
K175 E175 Biomuta DOID:363 / uterine cancer [ tcga ]
K254 E254 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K274 N274 Biomuta DOID:3070 / malignant glioma [ tcga ]
K433 R433 Biomuta DOID:363 / uterine cancer [ tcga ]